{"id":"W2155864303","doi":"10.1128/iai.02572-14","title":"Nonbinding Site-Directed Mutants of Transferrin Binding Protein B Exhibit Enhanced Immunogenicity and Protective Capabilities","year":2014,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Toronto","funders":"","keywords":"Biology; Immunogenicity; Transferrin; Antigen; Immune system; Transferrin receptor; Mutant; Microbiology; Immunology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000148221,0.0003521803,0.0001925876,0.0001728987,0.00008624679,0.0002050749,0.0002409546,0.0003508529,0.0007425079],"category_scores_gemma":[0.000147906,0.00012815,0.0002016784,0.0001036241,0.0002693915,0.0001128053,0.0001181358,0.0004570438,0.0002750719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002215712,"about_ca_system_score_gemma":0.0001256199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000582449,"about_ca_topic_score_gemma":0.0003991568,"domain_scores_codex":[0.9998866,0.0000241569,0.00001137843,0.00001477858,0.00003277199,0.00003027459],"domain_scores_gemma":[0.9998135,0.00004104806,0.00005510173,0.00002258646,0.00001824893,0.00004959385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001539846,0.00005175734,0.0001254477,0.00001455073,0.000005783661,0.00003627777,0.000008374532,0.00007557218,0.9990429,0.0000649006,0.0000220176,0.0003983006],"study_design_scores_gemma":[0.00006123095,0.001176534,0.003681595,0.000006827455,0.00001937186,0.0007130463,0.00002527239,0.001330143,0.9910807,0.00005541043,0.001841527,0.000008450053],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982097,0.0003632381,0.0007637526,0.00003428542,0.00001490788,0.00001078477,0.00007562337,0.00002656514,0.0005011013],"genre_scores_gemma":[0.9977422,0.0001854408,0.0007705413,0.000039074,0.000007678198,0.00001147433,0.0002933335,0.00001744829,0.0009327722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007425079,"threshold_uncertainty_score":0.002483904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01144339842789454,"score_gpt":0.2306962761239117,"score_spread":0.2192528776960171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}