{"id":"W2155864303","doi":"10.1128/iai.02572-14","title":"Nonbinding Site-Directed Mutants of Transferrin Binding Protein B Exhibit Enhanced Immunogenicity and Protective Capabilities","year":2014,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Toronto","funders":"","keywords":"Biology; Immunogenicity; Transferrin; Antigen; Immune system; Transferrin receptor; Mutant; Microbiology; Immunology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004354531,0.0001845444,0.000326649,0.0001848395,0.0004953225,0.00002771486,0.00004542287,0.0002215143,0.0002086262],"category_scores_gemma":[0.000222453,0.0001688216,0.00006407899,0.0002045665,0.0002339979,0.0002037078,0.00005607821,0.0003342367,0.00001370191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003384513,"about_ca_system_score_gemma":0.00002069305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0048543,"about_ca_topic_score_gemma":0.000536339,"domain_scores_codex":[0.9987633,0.0004799799,0.0003124888,0.0002161023,0.00001720781,0.0002109587],"domain_scores_gemma":[0.9994235,0.0001236432,0.0001243252,0.0001836986,0.0001227701,0.00002203583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001757849,0.0001031088,0.005108833,0.00006908004,0.00008540822,3.598595e-8,0.0009730756,5.621221e-7,0.9842299,0.0001778876,0.000002318263,0.009073969],"study_design_scores_gemma":[0.001255789,0.0005052932,0.0839826,0.0001007807,0.00003355367,0.0000344873,0.0001862538,0.00001088135,0.9129027,0.0001561802,0.0006456561,0.0001858338],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979867,0.0001109783,0.0004464333,0.0000171391,0.0002993795,0.0005380171,0.00002735188,0.000141587,0.0004324121],"genre_scores_gemma":[0.9995899,0.00006209755,0.00003182017,0.000004304845,0.00001871195,0.00006756649,0.00002334548,0.00001302445,0.0001892583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07887377,"threshold_uncertainty_score":0.7338281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01144339842789454,"score_gpt":0.2306962761239117,"score_spread":0.2192528776960171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}