{"id":"W2155867893","doi":"10.1128/aac.46.11.3568-3573.2002","title":"Resistance to β-Lactamase Inhibitor Protein Does Not Parallel Resistance to Clavulanic Acid in TEM β-Lactamase Mutants","year":2002,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Fondation pour la Recherche Médicale","keywords":"Clavulanic acid; Microbiology; Beta-Lactamase Inhibitors; Mutant; Beta-lactamase; Drug resistance; Chemistry; Biology; Antibiotics; Escherichia coli; Biochemistry; Gene; Amoxicillin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001660589,0.0006179832,0.0004972149,0.000466215,0.0001289655,0.0005382649,0.0004357294,0.0006879761,0.001221565],"category_scores_gemma":[0.0006877053,0.0004802695,0.0006916503,0.0002917881,0.0003299444,0.0002887562,0.0004284459,0.0008728289,0.0005847064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001944494,"about_ca_system_score_gemma":0.0001406202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000362677,"about_ca_topic_score_gemma":0.0002670018,"domain_scores_codex":[0.99957,0.00007018238,0.00009007764,0.0001090334,0.0001082867,0.00005242405],"domain_scores_gemma":[0.9992608,0.0001194616,0.0003310364,0.0001055917,0.00006732857,0.0001156967],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007642906,0.00002633737,0.0006000812,0.00001522333,0.00001238022,0.0001344487,0.00001566107,0.00006057262,0.9985319,0.00002858013,0.00001005007,0.0004883631],"study_design_scores_gemma":[0.00002062347,0.0007387246,0.01584256,0.00001080596,0.00004311878,0.003927518,0.000104757,0.00121532,0.9773036,0.00004839336,0.0007257159,0.0000189097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977022,0.0001305482,0.001470089,0.00002938258,0.00001300717,0.00001668635,0.0001685969,0.00004334301,0.0004263006],"genre_scores_gemma":[0.9956481,0.00009881164,0.002761003,0.00002476417,0.000005630523,0.00002720992,0.0004198323,0.00006746637,0.0009472899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001221565,"threshold_uncertainty_score":0.004086554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01022885743189353,"score_gpt":0.2370004474868986,"score_spread":0.2267715900550051,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}