{"id":"W2155902341","doi":"10.1200/jco.2005.07.096","title":"Incidence and Prognostic Impact of Amenorrhea During Adjuvant Therapy in High-Risk Premenopausal Breast Cancer: Analysis of a National Cancer Institute of Canada Clinical Trials Group Study—NCIC CTG MA.5","year":2005,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kingston General Hospital; Juravinski Cancer Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Amenorrhea; Hazard ratio; Breast cancer; Internal medicine; Cyclophosphamide; Epirubicin; Gynecology; Incidence (geometry); Oncology; Cumulative incidence; Cancer; Chemotherapy; Cohort; Pregnancy; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006875522,0.0007021551,0.001553845,0.0008236973,0.0008196673,0.0011892,0.001242553,0.0009800863,0.001455509],"category_scores_gemma":[0.010982,0.0004854706,0.002711693,0.001995665,0.0007196588,0.0003250439,0.0005639435,0.00106772,0.0001304148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00337906,"about_ca_system_score_gemma":0.00511626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.1446093,"about_ca_topic_score_gemma":0.2621342,"domain_scores_codex":[0.9951154,0.002614059,0.0003341224,0.0004812251,0.001114331,0.0003408063],"domain_scores_gemma":[0.990582,0.00282524,0.003532446,0.001009631,0.0009090458,0.001141662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1353928,0.0004980453,0.8248438,0.0009320253,0.01900967,0.0001403038,0.0001276338,0.0005915585,0.0008494105,0.0001453427,0.00167547,0.01579414],"study_design_scores_gemma":[0.01219009,0.004533455,0.9742991,0.0001223985,0.006280767,0.000159996,0.00006155231,0.0006716539,0.0001385351,0.00008256167,0.001423268,0.0000366017],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9767553,0.01702634,0.0002464895,0.0003023733,0.00004650122,0.0006509547,0.003919409,0.00001407371,0.001038485],"genre_scores_gemma":[0.9935913,0.002255968,0.0002634871,0.0002341164,0.00006716296,0.0002704838,0.002942538,0.000007489851,0.00036744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1446093,"threshold_uncertainty_score":0.2875353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1525548274960943,"score_gpt":0.5236406910052744,"score_spread":0.3710858635091801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}