{"id":"W2155905959","doi":"10.1128/mcb.26.6.2399-2407.2006","title":"Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 Regulates Tumor Necrosis Factor mRNA Stability and Translation Mainly by Altering Tristetraprolin Expression, Stability, and Binding to Adenine/Uridine-Rich Element","year":2006,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":387,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal General Hospital","funders":"Deutsche Forschungsgemeinschaft","keywords":"Tristetraprolin; Biology; Protein kinase A; Tumor necrosis factor alpha; p38 mitogen-activated protein kinases; Molecular biology; Kinase; Messenger RNA; Untranslated region; AU-rich element; Cell biology; Biochemistry; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003978146,0.0004214816,0.000401371,0.000129065,0.0002555816,0.0001003636,0.0001593295,0.0002696283,0.00003260542],"category_scores_gemma":[0.0001050064,0.0003842244,0.00008106026,0.0002196527,0.0002037839,0.00002052697,0.0002046833,0.0002166083,8.274214e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000445685,"about_ca_system_score_gemma":0.00005824918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000304231,"about_ca_topic_score_gemma":0.00003486899,"domain_scores_codex":[0.9971721,0.0004105681,0.0004981402,0.001053251,0.0001928478,0.0006731058],"domain_scores_gemma":[0.9990284,0.00002495904,0.0001397209,0.0003985707,0.0001126404,0.0002956437],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006065152,0.0001125567,0.002632553,0.0001401506,0.00004711046,0.00001666064,0.0000751763,0.000002116787,0.9952096,0.0000139304,0.00002052057,0.001123158],"study_design_scores_gemma":[0.001422835,0.0008453165,0.0004220046,0.00005485165,0.00001617412,0.000008148571,0.00007538983,0.00009382578,0.9956475,0.00007823615,0.0009019301,0.0004338014],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922097,0.002294634,0.00317178,0.000236496,0.00003158526,0.001827644,0.0001753335,0.00003501137,0.00001783282],"genre_scores_gemma":[0.9979142,0.00002838863,0.001076956,0.00003699975,0.00004646571,0.0002395688,0.0005107827,0.00004894786,0.00009770743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0057045,"threshold_uncertainty_score":0.9998609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0132619171591228,"score_gpt":0.2413004916299455,"score_spread":0.2280385744708227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}