{"id":"W2155905959","doi":"10.1128/mcb.26.6.2399-2407.2006","title":"Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 Regulates Tumor Necrosis Factor mRNA Stability and Translation Mainly by Altering Tristetraprolin Expression, Stability, and Binding to Adenine/Uridine-Rich Element","year":2006,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":387,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal General Hospital","funders":"Deutsche Forschungsgemeinschaft","keywords":"Tristetraprolin; Biology; Protein kinase A; Tumor necrosis factor alpha; p38 mitogen-activated protein kinases; Molecular biology; Kinase; Messenger RNA; Untranslated region; AU-rich element; Cell biology; Biochemistry; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001101734,0.0005011127,0.0001864777,0.0001866544,0.0001362071,0.0002720545,0.0001740607,0.0001912755,0.001003178],"category_scores_gemma":[0.0001184528,0.0001524893,0.0001853272,0.0001136915,0.0002086669,0.0002047209,0.0001694458,0.0002895982,0.0004096026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002581767,"about_ca_system_score_gemma":0.0001185289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001208176,"about_ca_topic_score_gemma":0.0002018198,"domain_scores_codex":[0.999879,0.00002226024,0.00001031209,0.00003544944,0.00003035212,0.00002247687],"domain_scores_gemma":[0.9998752,0.00001397854,0.00006325383,0.00001171554,0.00001110555,0.00002475124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000478767,0.000006629198,0.00009472448,0.00001148135,0.00000155602,0.00002281191,0.000003293951,0.00002919365,0.9992734,0.00007018083,0.0000109716,0.0004278783],"study_design_scores_gemma":[0.00001420952,0.0001137099,0.002943705,0.000003270315,0.00001035549,0.000318796,0.00001124197,0.0007816505,0.994073,0.00007641457,0.001650305,0.000003432988],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894845,0.002054251,0.006595279,0.00009243445,0.00003220243,0.00002051343,0.0002840133,0.0001400796,0.001296669],"genre_scores_gemma":[0.9927086,0.001134529,0.003060625,0.00002586125,0.00001550117,0.00002794354,0.0004123306,0.00003019133,0.002584467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001003178,"threshold_uncertainty_score":0.00335598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0132619171591228,"score_gpt":0.2413004916299455,"score_spread":0.2280385744708227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}