{"id":"W2155920248","doi":"10.1124/jpet.109.150995","title":"The Effect of Allelic Variation in Aldo-Keto Reductase 1C2 on the in Vitro Metabolism of Dihydrotestosterone","year":2009,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Aldose Reductase and Taurine","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Nonsynonymous substitution; Dihydrotestosterone; Androgen receptor; Biology; Aldo-keto reductase; Enzyme; Reductase; In vitro; Nucleotide; In vivo; Biochemistry; Allele; Androgen; Genetics; Gene; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004759827,0.0001003631,0.0001949223,0.00004953556,0.00003693483,0.000004043548,0.0001277388,0.00006921875,0.000006448316],"category_scores_gemma":[0.000009916463,0.00005656965,0.00005907197,0.00006502939,0.0001051488,0.000006336291,0.00002387418,0.0001524601,1.845977e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001379947,"about_ca_system_score_gemma":0.00002762855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004064262,"about_ca_topic_score_gemma":5.314355e-7,"domain_scores_codex":[0.9991232,0.0002704832,0.0003198027,0.00008094199,0.00008912706,0.0001164646],"domain_scores_gemma":[0.9995635,0.0000800315,0.0002323944,0.00008019175,0.00002287296,0.00002103786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002920171,0.0001967258,0.0000422591,0.0000032686,0.0001111103,0.000005087645,0.0002491291,0.00004574483,0.9946249,0.00004526292,0.00006395472,0.00169239],"study_design_scores_gemma":[0.001996179,0.001673536,0.0008713068,0.00000818954,0.00004543614,0.00003382686,0.00008851033,0.00004172309,0.9941375,0.00008081705,0.0009736503,0.0000493877],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878236,0.01063589,0.000004375698,0.001186949,0.0001526268,0.0001498812,0.000002672439,5.733049e-7,0.00004343602],"genre_scores_gemma":[0.9979444,0.001371292,0.00003174236,0.000517122,0.0001160955,0.000004259758,0.000002109041,0.000005309232,0.00000774433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01012073,"threshold_uncertainty_score":0.2306843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009968182532875677,"score_gpt":0.3067661798539648,"score_spread":0.2967979973210891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}