{"id":"W2155959016","doi":"10.4049/jimmunol.1301155","title":"SHP2 Phosphatase Promotes Mast Cell Chemotaxis toward Stem Cell Factor via Enhancing Activation of the Lyn/Vav/Rac Signaling Axis","year":2014,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Heart, Lung, and Blood Institute","keywords":"LYN; Stem cell factor; Cell biology; Chemotaxis; Mast cell; Phosphorylation; Chemistry; Phosphatase; Protein tyrosine phosphatase; Biology; Cancer research; Stem cell; Receptor; Proto-oncogene tyrosine-protein kinase Src; Immunology; Biochemistry; Haematopoiesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006658752,0.0002131649,0.0003066477,0.00004756237,0.0001263534,0.00001525951,0.0007683194,0.0001693344,0.0000387503],"category_scores_gemma":[0.0001614417,0.0001313254,0.000171767,0.0001247638,0.0001825955,0.00001929022,0.0002721543,0.0003249842,0.000005778838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003610042,"about_ca_system_score_gemma":0.0001165047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005754888,"about_ca_topic_score_gemma":0.000003878317,"domain_scores_codex":[0.99841,0.0003480899,0.0005905982,0.0001654275,0.0002054701,0.0002804201],"domain_scores_gemma":[0.9979687,0.0001284088,0.001077425,0.0005320505,0.0002513065,0.00004213115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003462109,0.00008929233,0.0001320518,0.0000534471,0.00008839279,6.394716e-7,0.0002807223,0.00009372365,0.9935588,0.00002334888,0.00009961865,0.005233798],"study_design_scores_gemma":[0.0007143599,0.0007643884,0.0007839559,0.00006405239,0.00006191759,0.00004665531,0.0002006582,0.00002934522,0.9959453,0.0001327616,0.001120521,0.0001360543],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9705366,0.01274081,0.01571066,0.0004031385,0.0002810003,0.0002523024,0.00003137416,0.000005565442,0.00003853438],"genre_scores_gemma":[0.9987789,0.0002212257,0.0005720389,0.0001318791,0.0001701229,0.00000402406,0.00001307095,0.00002731828,0.0000814029],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0282423,"threshold_uncertainty_score":0.5355293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008320367531323859,"score_gpt":0.2075021209091802,"score_spread":0.1991817533778563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}