{"id":"W2155993522","doi":"10.1158/1055-9965.epi-14-1309","title":"Mendelian Randomization Study of Body Mass Index and Colorectal Cancer Risk","year":2015,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cancer Care Ontario; Lunenfeld-Tanenbaum Research Institute","funders":"National Human Genome Research Institute; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institute on Aging; National Cancer Institute; Lundbeckfonden; National Institutes of Health; U.S. Public Health Service","keywords":"Mendelian randomization; Body mass index; Medicine; Colorectal cancer; Oncology; Randomization; Mendelian inheritance; Index (typography); Internal medicine; Cancer; Genetics; Biology; Clinical trial; Genotype; Gene; Genetic variants; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002989216,0.0002087074,0.0005535395,0.00009954446,0.00009761741,0.000004110638,0.0001387381,0.0003510069,0.00002450486],"category_scores_gemma":[0.001320787,0.0001919543,0.0001081392,0.000145669,0.0001684654,0.000008608004,0.00009204405,0.0001155036,0.000001493734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007442212,"about_ca_system_score_gemma":0.0001703438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001725073,"about_ca_topic_score_gemma":0.00172271,"domain_scores_codex":[0.9963828,0.001933484,0.0007316317,0.0005378086,0.00008979315,0.0003245238],"domain_scores_gemma":[0.9984565,0.0001602203,0.0007817043,0.0002343949,0.0002180461,0.0001491214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001065523,0.0001215222,0.9800379,0.00001067115,0.000718291,3.226939e-7,0.00009570943,0.001848888,0.006705514,0.00001361694,0.004053835,0.005328188],"study_design_scores_gemma":[0.008754263,0.001230774,0.9787052,0.00002853152,0.0003452175,0.0000033265,0.0009019419,0.004513847,0.0009775914,0.003013782,0.001234435,0.0002910407],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9806778,0.006682141,0.01081387,0.0004005813,0.0005473314,0.0007311717,0.00003795623,0.00001421598,0.00009494166],"genre_scores_gemma":[0.9947842,0.00308836,0.001164892,0.00009271366,0.0001772524,0.0003557385,0.0001275189,0.0000203894,0.0001889461],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0141064,"threshold_uncertainty_score":0.7827668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02889368768976901,"score_gpt":0.3408353353095793,"score_spread":0.3119416476198102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}