{"id":"W2155999763","doi":"10.1091/mbc.e14-08-1281","title":"Rab5-family guanine nucleotide exchange factors bind retromer and promote its recruitment to endosomes","year":2015,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Regina; University of Toronto; Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research; Ontario Genomics Institute; Ontario Genomics; Natural Sciences and Engineering Research Council of Canada; University Health Network","keywords":"Retromer; Endosome; Guanine nucleotide exchange factor; Cell biology; Sorting nexin; Biology; Vacuolar protein sorting; Transport protein; Vesicular Transport Proteins; GTPase; Intracellular","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001101787,0.0003820294,0.0001513933,0.0003585576,0.0002058293,0.0004406338,0.000267085,0.0003364235,0.004128799],"category_scores_gemma":[0.0001709166,0.0001652428,0.000294589,0.000207457,0.000151813,0.0002736257,0.0004205886,0.0003400296,0.002272259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004531648,"about_ca_system_score_gemma":0.0001291308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003943414,"about_ca_topic_score_gemma":0.0006967145,"domain_scores_codex":[0.9998715,0.00002091579,0.000006720437,0.00003286307,0.00003635897,0.00003164325],"domain_scores_gemma":[0.9999319,0.00001151193,0.00001504115,0.000009245859,0.00001147749,0.00002087118],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004720734,0.000009942766,0.0004477246,0.0000462928,0.000009811385,0.00009206204,0.000009775922,0.00006339223,0.9960018,0.000393976,0.0001166499,0.00276124],"study_design_scores_gemma":[0.00001411522,0.00007295624,0.00964139,0.00001341375,0.00001726345,0.0005486764,0.00005086968,0.001466035,0.9726874,0.0002087378,0.01527365,0.000005478636],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9755529,0.007694748,0.008889224,0.00021532,0.00005091591,0.00002609481,0.0003781611,0.000425785,0.006766775],"genre_scores_gemma":[0.9891299,0.001460152,0.003730771,0.00009257677,0.00001390835,0.00001397116,0.0008138971,0.00003135607,0.004713506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004128799,"threshold_uncertainty_score":0.01381218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03659533495528883,"score_gpt":0.2627956795002275,"score_spread":0.2262003445449387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}