{"id":"W2156003012","doi":"10.1007/s10549-010-0902-3","title":"Cytochrome P450 2D6 and outcomes of adjuvant tamoxifen therapy: results of a meta-analysis","year":2010,"lang":"en","type":"review","venue":"Breast Cancer Research and Treatment","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Tamoxifen; CYP2D6; Breast cancer; Medicine; Oncology; Internal medicine; Genotype; Hazard ratio; Meta-analysis; Adjuvant therapy; Cancer; Pharmacology; Confidence interval; Biology; Cytochrome P450; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001552362,0.0006253958,0.004639549,0.0008034114,0.0001836811,0.0000284012,0.0003603606,0.000438188,0.0008141427],"category_scores_gemma":[0.00002741391,0.0003679257,0.001237831,0.0008196352,0.0007766098,0.00004898902,0.0002180363,0.0008670084,0.000006979003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008304232,"about_ca_system_score_gemma":0.0005767357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001677505,"about_ca_topic_score_gemma":0.0003211338,"domain_scores_codex":[0.9958511,0.001202745,0.001011412,0.0007692223,0.0005191053,0.0006464284],"domain_scores_gemma":[0.9969046,0.001073106,0.0005629373,0.0005683097,0.0003693545,0.0005217608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006553307,0.001121059,0.0001685262,0.0007690351,0.181642,0.00003202435,0.0002133672,0.000004218701,0.0002932624,0.00008331079,0.0001055893,0.8149123],"study_design_scores_gemma":[0.002913537,0.000493413,0.002086761,0.00005985286,0.1608649,0.0000336591,0.00001195967,0.000009797177,0.0004850885,0.0001006436,0.8326356,0.0003047313],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006217097,0.9778647,5.041813e-7,0.0004075422,0.00008997757,0.001540539,0.01351298,0.00001271799,0.000353936],"genre_scores_gemma":[0.01758061,0.9800144,0.000048282,0.0000445078,0.0001181648,0.0009694454,0.0001414589,0.0000451442,0.001037928],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.83253,"threshold_uncertainty_score":0.9998773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.5229333359174899,"score_gpt":0.5894168278163905,"score_spread":0.06648349189890057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}