{"id":"W2156008341","doi":"10.1371/journal.pgen.1004752","title":"Gene Pathways That Delay Caenorhabditis elegans Reproductive Senescence","year":2014,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Simon Fraser University; Ellison Medical Foundation; Burroughs Wellcome Fund","keywords":"Biology; Senescence; Longevity; Caenorhabditis elegans; Genetics; Gene; RNA interference; Somatic cell; Klotho; Cell biology; RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002765697,0.0003781753,0.0002960126,0.00006139974,0.0002062605,0.00006751499,0.0005292015,0.0002799575,0.00003511919],"category_scores_gemma":[0.0001542513,0.0004013001,0.0001322456,0.0001134115,0.0002015529,0.000005718738,0.0002668999,0.0001900108,0.00008203933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002792359,"about_ca_system_score_gemma":0.00009769332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001505416,"about_ca_topic_score_gemma":0.00006684518,"domain_scores_codex":[0.9975434,0.0001539305,0.0003211865,0.001004241,0.0003837248,0.000593495],"domain_scores_gemma":[0.9980096,0.00002013401,0.0001177848,0.001387394,0.0002441456,0.0002209759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002230412,0.0001519431,0.009410167,0.00003340218,0.00009045177,0.000007797265,0.0005215092,0.0007629658,0.9863459,0.00005762453,0.001156254,0.001439618],"study_design_scores_gemma":[0.0003878235,0.0004142728,0.002472044,0.00001261941,0.00008270365,0.00006443185,0.00007315542,0.001435146,0.981326,0.0003731783,0.01282511,0.0005334872],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9768434,0.001429638,0.01965845,0.0002205665,0.0005071963,0.0003270244,0.0000553354,0.00006249278,0.000895955],"genre_scores_gemma":[0.98905,0.0008206218,0.007444507,0.0006773818,0.001264454,0.00003046008,0.0001623797,0.00009915415,0.0004510699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01221394,"threshold_uncertainty_score":0.9998439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01891009497486565,"score_gpt":0.2087787349010818,"score_spread":0.1898686399262161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}