{"id":"W2156033360","doi":"10.1038/emboj.2009.190","title":"Numb regulates cell–cell adhesion and polarity in response to tyrosine kinase signalling","year":2009,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":118,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Ontario Genomics Institute; Genome Canada","keywords":"Biology; Cell biology; NUMB; Signalling; Polarity (international relations); Cell adhesion; Cell; Tyrosine kinase; Signal transduction; Cell polarity; Kinase; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009171001,0.0002281353,0.0002225727,0.0002095436,0.000348683,0.0004965544,0.0001580117,0.000216963,0.000877309],"category_scores_gemma":[0.0001399473,0.0001415639,0.00008609033,0.0001317963,0.0003364663,0.000291656,0.0004553087,0.000293581,0.0003793621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005881946,"about_ca_system_score_gemma":0.0001645351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004566732,"about_ca_topic_score_gemma":0.0007041432,"domain_scores_codex":[0.9998621,0.00003098521,0.000007398096,0.00002851816,0.00004109856,0.0000299365],"domain_scores_gemma":[0.9999235,0.000005160609,0.00002463372,0.000003971785,0.000007632932,0.00003510094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007705905,0.000006208249,0.0004909571,0.0000355926,0.000002814155,0.0001500376,0.00002796433,0.00005867651,0.9968314,0.0003811726,0.00004196358,0.001896253],"study_design_scores_gemma":[0.00002730109,0.0001279709,0.05970278,0.00003576617,0.00001726676,0.001343637,0.0001964571,0.003981995,0.9211537,0.0006547851,0.01274537,0.00001291264],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827102,0.009226619,0.003410887,0.0002349619,0.00003716099,0.00001862939,0.0001754408,0.00008819152,0.004097846],"genre_scores_gemma":[0.9944535,0.001856377,0.0009084974,0.00003546056,0.00000661591,0.00001591008,0.0001188322,0.0000106215,0.002594155],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000877309,"threshold_uncertainty_score":0.004267693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008605877303778802,"score_gpt":0.2378419879714636,"score_spread":0.2292361106676848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}