{"id":"W2156073112","doi":"10.1158/1055-9965.epi-13-0340","title":"A Genome-wide Association Study of Early-Onset Breast Cancer Identifies <i>PFKM</i> as a Novel Breast Cancer Gene and Supports a Common Genetic Spectrum for Breast Cancer at Any Age","year":2014,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Institute of Environmental Health Sciences; National Cancer Institute; National Center for Advancing Translational Sciences; National Institute of Mental Health; Cancer Research UK","keywords":"Breast cancer; Cancer; Medicine; Genetic association; Genome-wide association study; Oncology; Gene; Internal medicine; Biology; Genetics; Genotype; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007127655,0.0004192986,0.0005025108,0.0007491637,0.0005089168,0.0007457365,0.0004219082,0.0004640527,0.002475895],"category_scores_gemma":[0.003050237,0.0002345702,0.0004356698,0.001192152,0.0005654856,0.0002626604,0.0003863793,0.0007303673,0.0004157836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002175849,"about_ca_system_score_gemma":0.0002306595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002160056,"about_ca_topic_score_gemma":0.002410522,"domain_scores_codex":[0.9995393,0.0001047391,0.00002436006,0.0001967686,0.00007554154,0.00005943947],"domain_scores_gemma":[0.9985847,0.0005771727,0.0004402081,0.0001450008,0.00007986269,0.0001730607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002640567,0.0001846122,0.8945963,0.0002052602,0.0006490731,0.0009132546,0.0001753015,0.0005496391,0.06751884,0.0004059987,0.0016257,0.03053549],"study_design_scores_gemma":[0.00004429407,0.000204378,0.9928715,0.00001541368,0.0001912328,0.001140264,0.00005664503,0.001035424,0.002969607,0.0003458076,0.001109704,0.00001567088],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945419,0.001090417,0.002126115,0.0001201565,0.00003033609,0.00001731354,0.001159911,0.00007666476,0.0008372529],"genre_scores_gemma":[0.9957724,0.0002283172,0.002482835,0.00006817518,0.00003307872,0.00001935008,0.001052649,0.00001501294,0.0003281184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002475895,"threshold_uncertainty_score":0.008282661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0156950344031178,"score_gpt":0.3068503474907324,"score_spread":0.2911553130876146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}