{"id":"W2156087931","doi":"10.4049/jimmunol.1003551","title":"IL-6 Production Is Positively Regulated by Two Distinct <i>Src</i> Homology Domain 2-Containing Tyrosine Phosphatase-1 (SHP-1)–Dependent CCAAT/Enhancer-Binding Protein β and NF-κB Pathways and an SHP-1–Independent NF-κB Pathway in Lipopolysaccharide-Stimulated Bone Marrow-Derived Macrophages","year":2011,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo; Children's Hospital of Eastern Ontario; University of Ottawa; Health Canada","funders":"","keywords":"Proto-oncogene tyrosine-protein kinase Src; Protein tyrosine phosphatase; Phosphorylation; Phosphatase; Transcription factor; Downregulation and upregulation; Cell biology; Tyrosine; Signal transduction; Ccaat-enhancer-binding proteins; Biology; Molecular biology; Chemistry; Biochemistry; Gene; DNA-binding protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001559742,0.0005416655,0.0007268928,0.000214022,0.0003279216,0.00006007273,0.000529527,0.0003709975,0.00005060168],"category_scores_gemma":[0.0002419857,0.0004437338,0.00009238059,0.0001984644,0.000656625,0.0001017442,0.0004658247,0.0006901061,0.00000388613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001157658,"about_ca_system_score_gemma":0.0001734558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006504034,"about_ca_topic_score_gemma":0.000155616,"domain_scores_codex":[0.9964792,0.0007591369,0.001067131,0.0006902881,0.0002818725,0.0007223308],"domain_scores_gemma":[0.9977936,0.00005157204,0.001101738,0.0006016291,0.000284219,0.0001672467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00518687,0.0003042073,0.00050845,0.00002974986,0.000277033,0.0002070777,0.0009592783,0.000009472256,0.9873437,0.000169393,0.00007853182,0.00492624],"study_design_scores_gemma":[0.003839447,0.003138027,0.001705573,0.0001691808,0.00009502521,0.002014817,0.000651743,0.00001547617,0.9871457,0.0006863645,0.00007553591,0.0004631643],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9592143,0.03861313,0.0003849194,0.0003440551,0.0002839653,0.0008279577,0.0002928291,0.00002561049,0.00001326233],"genre_scores_gemma":[0.997314,0.001115093,0.00101058,0.00007796079,0.0001315588,0.00004371212,0.0001477121,0.00007510582,0.00008427569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03809973,"threshold_uncertainty_score":0.9998015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01140432238978074,"score_gpt":0.2292108678994655,"score_spread":0.2178065455096847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}