{"id":"W2156087931","doi":"10.4049/jimmunol.1003551","title":"IL-6 Production Is Positively Regulated by Two Distinct <i>Src</i> Homology Domain 2-Containing Tyrosine Phosphatase-1 (SHP-1)–Dependent CCAAT/Enhancer-Binding Protein β and NF-κB Pathways and an SHP-1–Independent NF-κB Pathway in Lipopolysaccharide-Stimulated Bone Marrow-Derived Macrophages","year":2011,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo; Children's Hospital of Eastern Ontario; University of Ottawa; Health Canada","funders":"","keywords":"Proto-oncogene tyrosine-protein kinase Src; Protein tyrosine phosphatase; Phosphorylation; Phosphatase; Transcription factor; Downregulation and upregulation; Cell biology; Tyrosine; Signal transduction; Ccaat-enhancer-binding proteins; Biology; Molecular biology; Chemistry; Biochemistry; Gene; DNA-binding protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001467504,0.0005368628,0.0002960999,0.0002386411,0.0001270083,0.0003235429,0.0001228724,0.0002347217,0.0009821071],"category_scores_gemma":[0.0001068071,0.0002196537,0.0002918482,0.0001330242,0.0002979542,0.0001928077,0.000255174,0.0006645356,0.0003636227],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001496479,"about_ca_system_score_gemma":0.0001592611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000153361,"about_ca_topic_score_gemma":0.0002858453,"domain_scores_codex":[0.9997461,0.00003344316,0.00002632206,0.00005367538,0.00007273737,0.00006772611],"domain_scores_gemma":[0.9997939,0.0000222153,0.0000835853,0.00001952368,0.00001881425,0.00006193952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005701283,0.000008201564,0.0001192917,0.000009120913,0.000001070921,0.00001587289,0.0000043298,0.000007008829,0.9996051,0.00001502233,0.000004275151,0.0001538395],"study_design_scores_gemma":[0.00002488613,0.0002317386,0.01321939,0.000005284332,0.00001325088,0.0002927261,0.00002803442,0.0004120072,0.9849878,0.00004630354,0.0007335736,0.000004936369],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99503,0.001199536,0.002656207,0.00007061513,0.00002288933,0.00002103968,0.0003090387,0.00005532253,0.000635169],"genre_scores_gemma":[0.9952884,0.0006640531,0.00197299,0.00004012945,0.0000219353,0.00005480884,0.0005100482,0.00001509543,0.001432609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009821071,"threshold_uncertainty_score":0.003285468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01140432238978074,"score_gpt":0.2292108678994655,"score_spread":0.2178065455096847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}