{"id":"W2156121759","doi":"10.1186/1755-1536-4-9","title":"Thrombospondin 1 is a key mediator of transforming growth factor β-mediated cell contractility in systemic sclerosis via a mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK)-dependent mechanism","year":2011,"lang":"en","type":"article","venue":"Fibrogenesis & Tissue Repair","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Institutes of Health Research; Western University","funders":"","keywords":"MAPK/ERK pathway; Cell biology; Kinase; Extracellular matrix; Transforming growth factor; Medicine; Protein kinase A; MEK inhibitor; Fibroblast; Epidermal growth factor; Cancer research; Signal transduction; Thrombospondin 1; Growth factor; Endocrinology; Internal medicine; Biology; Cell culture; Angiogenesis; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002287851,0.0003881418,0.0001679768,0.0002383296,0.000210871,0.0001844549,0.0001724835,0.0002570481,0.001079301],"category_scores_gemma":[0.0001712275,0.0001418591,0.0002033479,0.0001128875,0.0002267829,0.0003384812,0.0002453676,0.0004966032,0.0002344293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001761116,"about_ca_system_score_gemma":0.000119785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001705402,"about_ca_topic_score_gemma":0.0002154733,"domain_scores_codex":[0.999907,0.00002660859,0.000006847833,0.00001692647,0.00002552931,0.00001708718],"domain_scores_gemma":[0.9999049,0.00001492031,0.00003301603,0.00000594461,0.00001648043,0.00002484288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003057988,0.00003283764,0.0008036811,0.0001097975,0.00001591855,0.0004999501,0.00004536052,0.00006962258,0.9934048,0.0006662426,0.0001037127,0.003942385],"study_design_scores_gemma":[0.0001084955,0.0007866979,0.04240696,0.00003168676,0.00006736512,0.003495372,0.0001217212,0.001592128,0.9426814,0.001163365,0.007530508,0.00001438751],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9777204,0.01167757,0.00627141,0.0003272556,0.00007053465,0.00005920476,0.0002217268,0.00004701696,0.003604902],"genre_scores_gemma":[0.9915287,0.002980759,0.002147272,0.00006492701,0.00004675103,0.0000415869,0.0003582647,0.000005271875,0.002826285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001079301,"threshold_uncertainty_score":0.003610611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02929878267316069,"score_gpt":0.2309924666155953,"score_spread":0.2016936839424346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}