{"id":"W2156134408","doi":"10.1101/gad.1298305","title":"Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling","year":2005,"lang":"en","type":"article","venue":"Genes & Development","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":154,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Women's College Hospital; University of Toronto; Sunnybrook Health Science Centre","funders":"National Cancer Institute; National Institutes of Health; California Institute of Technology","keywords":"Notch signaling pathway; Biology; Cell biology; Lineage (genetic); Progenitor cell; Transcription factor; Cellular differentiation; Cell fate determination; Hes3 signaling axis; Signal transduction; Genetics; Gene; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002282829,0.0001745398,0.0001169978,0.00004449928,0.000186151,0.00002106961,0.000115605,0.0001853199,0.00003392478],"category_scores_gemma":[0.000008911979,0.0001769942,0.00002633131,0.00007391071,0.00003718906,0.000008938223,0.0001010516,0.00005732218,0.00005032886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005303019,"about_ca_system_score_gemma":0.0001226909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005752578,"about_ca_topic_score_gemma":0.00004074642,"domain_scores_codex":[0.9989523,0.00003436495,0.0002755661,0.0003991752,0.0001053598,0.0002332699],"domain_scores_gemma":[0.9996166,0.000006753088,0.00008809914,0.0001531369,0.00005426257,0.00008119233],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004386373,0.00003327541,0.001562763,0.000006557744,0.00005595828,3.783127e-7,0.0001139083,0.00003017702,0.8886471,0.00001478778,0.001834248,0.107657],"study_design_scores_gemma":[0.0002955852,0.00004444568,0.005686237,0.000006892202,0.000007389892,0.000009249505,0.00004605757,0.00002251736,0.790736,0.000006640519,0.2029233,0.0002156495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922916,0.002544732,0.00424462,0.000282017,0.0001096773,0.0001847935,0.000008804422,0.00002057255,0.0003131472],"genre_scores_gemma":[0.9728284,0.0005603376,0.02420868,0.0003301184,0.0001783506,0.00002684595,0.001029869,0.00001708804,0.0008203436],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2010891,"threshold_uncertainty_score":0.7217616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0104137401396533,"score_gpt":0.2298784233648576,"score_spread":0.2194646832252043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}