{"id":"W2156134408","doi":"10.1101/gad.1298305","title":"Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling","year":2005,"lang":"en","type":"article","venue":"Genes & Development","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":154,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Women's College Hospital; University of Toronto; Sunnybrook Health Science Centre","funders":"National Cancer Institute; National Institutes of Health; California Institute of Technology","keywords":"Notch signaling pathway; Biology; Cell biology; Lineage (genetic); Progenitor cell; Transcription factor; Cellular differentiation; Cell fate determination; Hes3 signaling axis; Signal transduction; Genetics; Gene; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007651193,0.000216189,0.000145954,0.0001380456,0.0001196665,0.0002978738,0.000214265,0.0001181589,0.001214253],"category_scores_gemma":[0.0001120739,0.0001375957,0.0001440842,0.0001101345,0.0001859516,0.0001619017,0.0002852695,0.0003484811,0.0004405194],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002910508,"about_ca_system_score_gemma":0.0001967472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006776132,"about_ca_topic_score_gemma":0.001138168,"domain_scores_codex":[0.9999111,0.000008908582,0.00000686678,0.00002167269,0.00002878886,0.00002260196],"domain_scores_gemma":[0.9998398,0.00002943155,0.00004181847,0.00002938629,0.00001610478,0.00004344892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000522419,0.000005943233,0.000133336,0.00001018722,0.000001109406,0.00003576819,0.000006889999,0.00004455661,0.998827,0.0001282545,0.00002035131,0.0007343339],"study_design_scores_gemma":[0.00000813595,0.00004055974,0.001153299,0.000001901159,0.000003332228,0.0001058781,0.00000744657,0.0005757614,0.9974059,0.00003164492,0.0006643876,0.000001804886],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914316,0.0004897396,0.005478189,0.00002693277,0.00002078139,0.00002072291,0.0003636067,0.0001468279,0.002021614],"genre_scores_gemma":[0.9938114,0.0003381356,0.002376955,0.00002670789,0.000005760233,0.00002684231,0.000457564,0.00004687601,0.002909651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001214253,"threshold_uncertainty_score":0.004062116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0104137401396533,"score_gpt":0.2298784233648576,"score_spread":0.2194646832252043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}