{"id":"W2156134411","doi":"10.1016/s0145-2126(02)00222-9","title":"Preclinical evaluation of antineoplastic activity of inhibitors of DNA methylation (5-aza-2′-deoxycytidine) and histone deacetylation (trichostatin A, depsipeptide) in combination against myeloid leukemic cells","year":2003,"lang":"en","type":"article","venue":"Leukemia Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Trichostatin A; Histone deacetylase; DNA methylation; Cancer research; Azacitidine; Acetylation; Histone deacetylase inhibitor; Histone; Decitabine; Myeloid leukemia; Epigenetics; CpG site; Deoxycytidine; Chromatin; Biology; Chemistry; DNA; Biochemistry; Gene expression; Chemotherapy; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006175546,0.0001388842,0.0002827686,0.0003971881,0.00004948827,0.000008220848,0.0001034665,0.0002805912,0.000007260238],"category_scores_gemma":[0.003049951,0.0001498402,0.00006340658,0.0005588879,0.0002047002,0.00002048961,0.00006674667,0.0002424782,7.462243e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002934154,"about_ca_system_score_gemma":0.0007840238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001706512,"about_ca_topic_score_gemma":0.0001217952,"domain_scores_codex":[0.9964519,0.0013602,0.0007106712,0.0003816808,0.0008602814,0.0002352533],"domain_scores_gemma":[0.9977325,0.0004852347,0.0004183711,0.0002964937,0.001004622,0.00006273014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001661166,0.0001457919,0.01091667,0.0001151201,0.00001964824,1.916639e-7,0.0001629292,0.0056817,0.9654173,0.00008940879,0.00001509458,0.01727004],"study_design_scores_gemma":[0.002059483,0.0004120163,0.06621657,0.0000617914,0.00002412012,3.199559e-7,0.00007088638,0.01525205,0.9152125,0.0005427608,0.00003746186,0.0001101094],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959224,0.001105983,0.001757367,0.00001647125,0.00007922605,0.0006371953,0.00001146696,0.000003208547,0.0004666604],"genre_scores_gemma":[0.9980701,0.0007400989,0.0009992899,0.000001985964,0.00002568125,0.00002514063,0.00007832811,0.00001968947,0.00003974526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05529989,"threshold_uncertainty_score":0.6110307,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06027886334873608,"score_gpt":0.3861331952723275,"score_spread":0.3258543319235914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}