{"id":"W2156134411","doi":"10.1016/s0145-2126(02)00222-9","title":"Preclinical evaluation of antineoplastic activity of inhibitors of DNA methylation (5-aza-2′-deoxycytidine) and histone deacetylation (trichostatin A, depsipeptide) in combination against myeloid leukemic cells","year":2003,"lang":"en","type":"article","venue":"Leukemia Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Trichostatin A; Histone deacetylase; DNA methylation; Cancer research; Azacitidine; Acetylation; Histone deacetylase inhibitor; Histone; Decitabine; Myeloid leukemia; Epigenetics; CpG site; Deoxycytidine; Chromatin; Biology; Chemistry; DNA; Biochemistry; Gene expression; Chemotherapy; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009801058,0.001032436,0.001241459,0.0009423963,0.0004492917,0.0005037591,0.001120719,0.0006428408,0.002713244],"category_scores_gemma":[0.0005038389,0.0005159714,0.000748845,0.0006845226,0.0006663164,0.0006194111,0.0002777146,0.002022829,0.0005188793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005965568,"about_ca_system_score_gemma":0.001165353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002138733,"about_ca_topic_score_gemma":0.004289053,"domain_scores_codex":[0.9995918,0.0001476699,0.00002659482,0.00004500681,0.00005840466,0.0001305961],"domain_scores_gemma":[0.9995395,0.0001107001,0.00008289784,0.00004815062,0.00004245106,0.0001763768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.05642078,0.03767428,0.00186513,0.0005657127,0.0005344244,0.0004829545,0.0003387112,0.006073392,0.8398064,0.001234874,0.002294387,0.05270893],"study_design_scores_gemma":[0.01560948,0.3886092,0.006705332,0.00004716689,0.0007783173,0.0006940958,0.0001706347,0.003285105,0.5753231,0.0002573206,0.008481161,0.00003912295],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920326,0.003064294,0.001039804,0.000255264,0.0001130422,0.000478207,0.0006625269,0.0001222727,0.002231878],"genre_scores_gemma":[0.9928567,0.003148898,0.0008894788,0.00006085241,0.00006907171,0.0002958908,0.0009089419,0.00002047239,0.0017496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002713244,"threshold_uncertainty_score":0.009076655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06027886334873608,"score_gpt":0.3861331952723275,"score_spread":0.3258543319235914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}