{"id":"W2156142163","doi":"10.3899/jrheum.101156","title":"Febuxostat in Gout: Serum Urate Response in Uric Acid Overproducers and Underexcretors","year":2011,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Gout, Hyperuricemia, Uric Acid","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Takeda Pharmaceuticals North America; Amgen","keywords":"Febuxostat; Medicine; Gout; Hyperuricemia; Placebo; Uric acid; Internal medicine; Allopurinol; Urology; Benzbromarone; Clinical endpoint; Gastroenterology; Xanthine oxidase inhibitor; Randomized controlled trial; Xanthine oxidase; Biochemistry; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009816586,0.000283595,0.001046017,0.0002508445,0.0001898198,0.0003566649,0.0001857225,0.0003803437,0.001346421],"category_scores_gemma":[0.00104668,0.0001409221,0.0003905929,0.0001984743,0.0002639699,0.000204342,0.0001619179,0.0005485166,0.00008282492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002918744,"about_ca_system_score_gemma":0.0002900665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003000208,"about_ca_topic_score_gemma":0.0007355959,"domain_scores_codex":[0.999728,0.0001540073,0.00002523823,0.00003074823,0.00003088874,0.00003112281],"domain_scores_gemma":[0.9995895,0.0001657691,0.0001262307,0.00001544103,0.00002085369,0.00008229347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6869269,0.006454763,0.05314906,0.002138453,0.001318969,0.0004187835,0.0002090052,0.001426883,0.06496835,0.0002779303,0.001057759,0.1816531],"study_design_scores_gemma":[0.2218542,0.4698217,0.2593589,0.0004286561,0.002957121,0.001901424,0.0002451292,0.003867069,0.03038311,0.0005789471,0.008537667,0.00006626721],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908713,0.007840604,0.000178223,0.0001927748,0.00004457525,0.0001749189,0.00008546006,0.00001938806,0.0005928408],"genre_scores_gemma":[0.9972085,0.001609149,0.0004758835,0.0001444096,0.00006400602,0.0001004422,0.00008734213,0.000003146448,0.000307124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001346421,"threshold_uncertainty_score":0.005191565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02260747304011963,"score_gpt":0.2516234194320867,"score_spread":0.229015946391967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}