{"id":"W2156150950","doi":"10.1101/gad.1975111","title":"Regulation of E2Fs and senescence by PML nuclear bodies","year":2011,"lang":"en","type":"article","venue":"Genes & Development","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":160,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Biology; Promyelocytic leukemia protein; Retinoblastoma protein; E2F; Senescence; Cell biology; Nuclear protein; Cancer research; Retinoblastoma; Transcription factor; Cell cycle; Cell Cycle Protein; Tumor suppressor gene; Gene; Genetics; Carcinogenesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008342823,0.00009144123,0.00008235138,0.00001618966,0.00005652669,0.000005946636,0.00008831293,0.00007442859,0.00002866586],"category_scores_gemma":[0.00001027287,0.00008521043,0.00001654994,0.00002503972,0.00007192943,0.000003066266,0.00008586562,0.00002123509,0.000004653433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007060485,"about_ca_system_score_gemma":0.00005639213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007285264,"about_ca_topic_score_gemma":0.000002817966,"domain_scores_codex":[0.9994392,0.00001459479,0.000156815,0.0001932523,0.00008235249,0.0001137982],"domain_scores_gemma":[0.9997162,0.000002025474,0.00006501869,0.0001250455,0.0000568231,0.00003489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002634294,0.00002018357,0.006180258,0.0000478662,0.00002401334,4.487932e-7,0.0005845782,5.094806e-7,0.968091,0.00005854237,0.0008520278,0.0241143],"study_design_scores_gemma":[0.0001186792,0.00005321248,0.01197097,0.00001309515,0.000006127385,0.000006597072,0.0001303742,0.000005029689,0.9349287,0.0000648578,0.05258687,0.0001155457],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929774,0.003435079,0.001330504,0.00001282747,0.00004974147,0.00006571534,0.000001809245,0.000008217596,0.002118707],"genre_scores_gemma":[0.9888899,0.001132387,0.009154519,0.0000445437,0.00002287634,0.000006371945,0.00003020293,0.00001148564,0.0007076766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05173484,"threshold_uncertainty_score":0.3474781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01003324977154315,"score_gpt":0.1964242819417432,"score_spread":0.1863910321702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}