{"id":"W2156150950","doi":"10.1101/gad.1975111","title":"Regulation of E2Fs and senescence by PML nuclear bodies","year":2011,"lang":"en","type":"article","venue":"Genes & Development","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":160,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Biology; Promyelocytic leukemia protein; Retinoblastoma protein; E2F; Senescence; Cell biology; Nuclear protein; Cancer research; Retinoblastoma; Transcription factor; Cell cycle; Cell Cycle Protein; Tumor suppressor gene; Gene; Genetics; Carcinogenesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001461752,0.0002531626,0.0001365778,0.0002401799,0.0002905681,0.000512391,0.0001334428,0.0002592583,0.0007948334],"category_scores_gemma":[0.0001403077,0.0001363489,0.0002248674,0.0001225336,0.0003980429,0.0002683511,0.000337589,0.0003177298,0.0004435441],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004158782,"about_ca_system_score_gemma":0.0002268776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005614466,"about_ca_topic_score_gemma":0.0007806226,"domain_scores_codex":[0.9998722,0.00002697211,0.000008440617,0.00002583388,0.00003514436,0.00003128587],"domain_scores_gemma":[0.999898,0.00001583668,0.00002657482,0.00001906639,0.00001299414,0.00002750949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001230088,0.00001034901,0.0003204569,0.00001640267,0.000002628488,0.00007881734,0.00002991629,0.00004695768,0.9964817,0.0006173261,0.0000403609,0.002232028],"study_design_scores_gemma":[0.00001476679,0.00004465858,0.003491247,0.00000266398,0.000003303689,0.0002094802,0.00002452955,0.0002878318,0.9920884,0.0002418126,0.003588356,0.000002878145],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798689,0.006982867,0.007340929,0.0002049679,0.00003873621,0.00001737737,0.0002276899,0.0001853745,0.005133066],"genre_scores_gemma":[0.9922267,0.001804672,0.001947422,0.00004160697,0.000009569793,0.00001355866,0.00017219,0.00002084051,0.003763364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007948334,"threshold_uncertainty_score":0.003017426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01003324977154315,"score_gpt":0.1964242819417432,"score_spread":0.1863910321702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}