{"id":"W2156164378","doi":"10.1371/journal.pone.0016819","title":"Improved Innate and Adaptive Immunostimulation by Genetically Modified HIV-1 Protein Expressing NYVAC Vectors","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Sanofi Pasteur; Sanofi; Bill and Melinda Gates Foundation","keywords":"Biology; Immunogenicity; Virology; HIV Antigens; Interferon; Antigen presentation; Cross-presentation; Antigen; Viral vector; Immune system; Gene; Virus; Immunology; T cell; Recombinant DNA; Genetics; Viral disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001260835,0.0003775089,0.0001937596,0.0001601058,0.00006965463,0.0003269737,0.0002016553,0.000216529,0.0004640975],"category_scores_gemma":[0.0001205634,0.0001053432,0.0002089163,0.0000881942,0.0001594313,0.0002516965,0.0001375237,0.000569638,0.0001313298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000223172,"about_ca_system_score_gemma":0.0001496249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001782122,"about_ca_topic_score_gemma":0.0002592386,"domain_scores_codex":[0.9998473,0.00002415922,0.00001508542,0.00002746631,0.00005775424,0.00002808191],"domain_scores_gemma":[0.9999343,0.00001220505,0.00002489251,0.000008904814,0.000009591738,0.00001011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004932147,0.00003085387,0.00008147882,0.00001859247,0.000002749068,0.00001651347,0.000008784435,0.0001139654,0.9981853,0.0001135714,0.00001570822,0.001363154],"study_design_scores_gemma":[0.00001245477,0.0003150478,0.0008533615,0.000003332029,0.0000133527,0.000131788,0.00000750419,0.001056396,0.9958448,0.00002774723,0.001730914,0.000003345695],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940385,0.0006970637,0.004471703,0.00003339058,0.00002220187,0.00004462231,0.0001384265,0.00004125177,0.0005128087],"genre_scores_gemma":[0.9893161,0.0007266412,0.007477476,0.00002470531,0.00001524161,0.00004466014,0.000485102,0.00002209355,0.001887997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004640975,"threshold_uncertainty_score":0.001619279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05024739170028834,"score_gpt":0.228464956032642,"score_spread":0.1782175643323537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}