{"id":"W2156167346","doi":"10.1016/j.biomaterials.2013.07.019","title":"Click conjugated polymeric immuno-nanoparticles for targeted siRNA and antisense oligonucleotide delivery","year":2013,"lang":"en","type":"article","venue":"Biomaterials","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Oligonucleotide; Lipofectamine; Nucleic acid; Small interfering RNA; Gene silencing; Nuclease; Conjugated system; PEG ratio; Transfection; RNA; Gene delivery; Materials science; Combinatorial chemistry; Biophysics; Chemistry; Biology; Biochemistry; DNA; Gene; Polymer; Organic chemistry; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003243777,0.0004134408,0.0002275392,0.0003045259,0.0001842411,0.0002656324,0.0002733972,0.0004946098,0.001279321],"category_scores_gemma":[0.0001690385,0.000277983,0.00023599,0.000163703,0.0002029663,0.0003178186,0.0002293612,0.0004040649,0.0005695316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003691799,"about_ca_system_score_gemma":0.0002554191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000288879,"about_ca_topic_score_gemma":0.0007633145,"domain_scores_codex":[0.9998497,0.00001957329,0.00001225838,0.00002772724,0.00005756851,0.00003313507],"domain_scores_gemma":[0.9999099,0.00002405679,0.0000257162,0.000007251546,0.00001761555,0.00001538261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003297055,0.00001396491,0.00004041967,0.00004059959,0.000003806792,0.00005735586,0.00001151186,0.0001086455,0.9974673,0.0003721061,0.00007948149,0.001771873],"study_design_scores_gemma":[0.000004532497,0.00006679132,0.0002055725,0.000002007596,0.000007381504,0.00009744371,0.000003402216,0.0007946001,0.9973884,0.0000342509,0.001391447,0.000004234853],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9336759,0.004583425,0.05383312,0.0002957666,0.000147126,0.000129047,0.0001989393,0.0005901795,0.006546402],"genre_scores_gemma":[0.9690552,0.002071142,0.01957131,0.0001349616,0.00002917581,0.0001117753,0.0001873426,0.00006656674,0.00877254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001279321,"threshold_uncertainty_score":0.004279792,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009964636454445933,"score_gpt":0.2298373775125762,"score_spread":0.2198727410581303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}