{"id":"W2156227559","doi":"10.1016/s0168-8278(10)60189-4","title":"187 A PHASE I/II, OPEN-LABEL, DOSE-ESCALATION TRIAL USING THE ONCE-DAILY ORAL CHELATOR DEFERASIROX TO TREAT IRON OVERLOAD IN HFE-RELATED HEREDITARY HEMOCHROMATOSIS: FINAL RESULTS","year":2010,"lang":"en","type":"article","venue":"Journal of Hepatology","topic":"Iron Metabolism and Disorders","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Hospital","funders":"","keywords":"Deferasirox; Open label; Medicine; Deferoxamine; Hereditary hemochromatosis; Hemochromatosis; Internal medicine; Gastroenterology; Clinical trial; Thalassemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0012538,0.001267869,0.002063816,0.0003705835,0.0004071826,0.001002458,0.0006365345,0.001535887,0.005417884],"category_scores_gemma":[0.0008506735,0.0004811855,0.001901113,0.0002710122,0.0008455156,0.0006795611,0.0002155304,0.003175824,0.001283349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007128144,"about_ca_system_score_gemma":0.000969369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000938979,"about_ca_topic_score_gemma":0.00229886,"domain_scores_codex":[0.9996616,0.0001546507,0.00001992193,0.00005195382,0.00003156482,0.00008037516],"domain_scores_gemma":[0.9995242,0.0001428496,0.00005510202,0.00006027863,0.00003420221,0.0001834525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7855752,0.02651578,0.002344922,0.001541177,0.002622035,0.000370711,0.0002164261,0.002661655,0.03044806,0.0007461329,0.01239937,0.1345585],"study_design_scores_gemma":[0.8689121,0.1221917,0.002658579,0.00004219448,0.0004895439,0.0001640484,0.00002901113,0.0007372004,0.001698,0.0003390873,0.002709314,0.00002908981],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9782771,0.004869075,0.002170951,0.002079781,0.0005284607,0.003512396,0.003566832,0.0002817627,0.004713627],"genre_scores_gemma":[0.9730315,0.003221303,0.005296863,0.003807574,0.0003643438,0.002857141,0.005063398,0.00008829245,0.006269524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005417884,"threshold_uncertainty_score":0.01812464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06147680168761157,"score_gpt":0.371779389914962,"score_spread":0.3103025882273505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}