{"id":"W2156232348","doi":"10.1139/y2012-047","title":"Cardoguard, an Ayurvedic antihypertensive formulation, prevents cardiac remodeling in spontaneously hypertensive rats by inhibition of ERK and PKCε signaling pathways","year":2012,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Medicinal Plants and Neuroprotection","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Department of Science and Technology, Ministry of Science and Technology, India","keywords":"Medicine; Muscle hypertrophy; Pharmacology; Left ventricular hypertrophy; Ventricular remodeling; Fibrosis; Adverse effect; Signal transduction; MAPK/ERK pathway; Internal medicine; Endocrinology; Cardiology; Blood pressure; Heart failure; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009490639,0.0003428854,0.0004103788,0.0004960669,0.0001962109,0.0001604079,0.0002012926,0.0002397593,0.001306592],"category_scores_gemma":[0.00006625142,0.0001251445,0.0002157626,0.0002088771,0.000219354,0.0001945889,0.000171164,0.0005821194,0.0001374203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001547347,"about_ca_system_score_gemma":0.0002870401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006596018,"about_ca_topic_score_gemma":0.001615475,"domain_scores_codex":[0.9999571,0.0000071186,0.000005154034,0.000007538988,0.00001105372,0.0000120443],"domain_scores_gemma":[0.9999545,0.000003709658,0.00001613849,0.000003931074,0.000006124499,0.00001577424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00368732,0.002610485,0.001094785,0.0006425388,0.00007086099,0.0002539849,0.00007696987,0.0001273198,0.9554496,0.0004227892,0.0004797871,0.03508354],"study_design_scores_gemma":[0.002383898,0.04458693,0.07279106,0.0001726994,0.0004478835,0.001123823,0.0002864279,0.001866348,0.8569606,0.0005493753,0.01877303,0.0000580971],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872414,0.007841753,0.001515164,0.0002807806,0.00008197797,0.0001045422,0.0003814535,0.0001255867,0.002427206],"genre_scores_gemma":[0.9844924,0.00875411,0.003004169,0.0001624426,0.00003392008,0.00008649844,0.0005248445,0.000009065757,0.002932542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001306592,"threshold_uncertainty_score":0.004370987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02546567449642008,"score_gpt":0.2590215107543289,"score_spread":0.2335558362579088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}