{"id":"W2156281737","doi":"10.1016/j.amjcard.2009.02.061","title":"Safety and Tolerability of Dalcetrapib††Conflicts of interest: Dr. Stein has received grants for studies of lipid-modifying agents, has received consulting fees and honoraria for professional input regarding agents to modify lipid profile, and/or has delivered lectures for the American Association for Clinical Chemistry, Washington, District of Columbia; Abbott Laboratories, Abbott Park, Illinois; AstraZeneca, Wilmington, Delaware; the United States Food and Drug Administration, Washington, District of Columbia; F. Hoffmann-La Roche Ltd., Basel, Switzerland; Isis Pharmaceuticals, Inc., Carlsbad, California; Merck & Co., Whitehouse Station, New Jersey; the National Lipid Association, Jacksonville, Florida; Novartis International AG, Basel Switzerland; Reliant Pharmaceuticals, Inc., Liberty Corner, New Jersey; Daiichi Sankyo Co., Ltd., Tokyo, Japan; Schering-Plough Corporation, Kenilworth, New Jersey; Takeda Pharmaceutical Company Ltd., Osaka, Japan; and Wyeth, Madison, New Jersey. Dr. Stroes has received consulting fees and honoraria from F. Hoffmann-La Roche Ltd. and Novartis International AG. Dr. Steiner has received consulting fees and honoraria from F. Hoffmann-La Roche Ltd.; Solvay, Brussels, Belgium; Ethypharm S.A., Saint-Cloud, France; and Merck Frosst Canada Ltd. (Kirkland, Quebec, Canada)/Schering-Plough Corporation. Dr. Buckley has received research grants from AstraZeneca; Merck Sharp & Dohme, Dublin, Ireland; and Pfizer, Inc., New York, New York. Dr. Buckley has received honoraria and consulting fees and/or delivered lectures for AstraZeneca; Bristol-Myers Squibb, New York, New York; F. Hoffmann-La Roche Ltd.; Novartis International AG; Pfizer, Inc.; and Sanofi-Aventis, Paris, France. Dr. Capponi has received consulting fees and honoraria from F. Hoffmann-La Roche Ltd. Dr. Burgess is an employee of Hoffmann-La Roche Inc., Nutley, New Jersey. Drs. Niesor and Kallend are employees of F. Hoffmann-La Roche Ltd. Dr. Kastelein has received research grants, honoraria, or consulting fees for professional input and/or has delivered lectures for Pfizer, Inc.; Merck Sharp & Dohme; F. Hoffmann-La Roche Ltd.; Novartis International AG; Isis Pharmaceuticals, Inc.; Kowa Pharmaceutical Company Ltd., Nagoya, Japan; Schering-Plough Corporation; and AstraZeneca.","year":2009,"lang":"en","type":"article","venue":"The American Journal of Cardiology","topic":"Pharmacology and Obesity Treatment","field":"Medicine","cited_by":137,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital; University of Toronto","funders":"","keywords":"Medicine; Cholesterylester transfer protein; Pharmacology; Tolerability; Aldosterone; Internal medicine; Aldosterone synthase; Placebo; Adverse effect; Atorvastatin; Endocrinology; Cholesterol; Blood pressure; Renin–angiotensin system; Lipoprotein; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","sts","scholarly_communication","research_integrity"],"consensus_categories":["metaepi_narrow","sts","research_integrity"],"category_scores_codex":[0.007522371,0.002110637,0.004711763,0.0007806447,0.002696376,0.002501167,0.001196914,0.001313077,0.00005366796],"category_scores_gemma":[0.01412722,0.001810158,0.000331251,0.001192596,0.006187164,0.001340455,0.0008929108,0.002733393,3.121318e-7],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007327021,"about_ca_system_score_gemma":0.007602104,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.1172699,"about_ca_topic_score_gemma":0.1044318,"domain_scores_codex":[0.9840938,0.003667757,0.005373934,0.00308376,0.002009164,0.001771526],"domain_scores_gemma":[0.9575284,0.02757693,0.006747453,0.0007640917,0.005343173,0.002039918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1259706,0.002053133,0.3358739,0.002625522,0.03108729,0.00006494425,0.0679604,0.001581211,0.1179764,0.0000689129,0.2653561,0.04938161],"study_design_scores_gemma":[0.2035788,0.007586272,0.3800166,0.008875987,0.01735291,0.001080822,0.04891123,0.06878746,0.03083367,0.00216881,0.2236885,0.007118913],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9275226,0.01784113,0.006671182,0.02684612,0.0007187381,0.006234835,0.01405325,0.0001081256,0.000004024081],"genre_scores_gemma":[0.94581,0.01772707,0.0278956,0.0009315529,0.0009606577,0.0003629292,0.005579961,0.0002834376,0.0004487807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08714273,"threshold_uncertainty_score":0.9999834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.156122537219245,"score_gpt":0.3774624182483624,"score_spread":0.2213398810291174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}