{"id":"W2156281737","doi":"10.1016/j.amjcard.2009.02.061","title":"Safety and Tolerability of Dalcetrapib††Conflicts of interest: Dr. Stein has received grants for studies of lipid-modifying agents, has received consulting fees and honoraria for professional input regarding agents to modify lipid profile, and/or has delivered lectures for the American Association for Clinical Chemistry, Washington, District of Columbia; Abbott Laboratories, Abbott Park, Illinois; AstraZeneca, Wilmington, Delaware; the United States Food and Drug Administration, Washington, District of Columbia; F. Hoffmann-La Roche Ltd., Basel, Switzerland; Isis Pharmaceuticals, Inc., Carlsbad, California; Merck & Co., Whitehouse Station, New Jersey; the National Lipid Association, Jacksonville, Florida; Novartis International AG, Basel Switzerland; Reliant Pharmaceuticals, Inc., Liberty Corner, New Jersey; Daiichi Sankyo Co., Ltd., Tokyo, Japan; Schering-Plough Corporation, Kenilworth, New Jersey; Takeda Pharmaceutical Company Ltd., Osaka, Japan; and Wyeth, Madison, New Jersey. Dr. Stroes has received consulting fees and honoraria from F. Hoffmann-La Roche Ltd. and Novartis International AG. Dr. Steiner has received consulting fees and honoraria from F. Hoffmann-La Roche Ltd.; Solvay, Brussels, Belgium; Ethypharm S.A., Saint-Cloud, France; and Merck Frosst Canada Ltd. (Kirkland, Quebec, Canada)/Schering-Plough Corporation. Dr. Buckley has received research grants from AstraZeneca; Merck Sharp & Dohme, Dublin, Ireland; and Pfizer, Inc., New York, New York. Dr. Buckley has received honoraria and consulting fees and/or delivered lectures for AstraZeneca; Bristol-Myers Squibb, New York, New York; F. Hoffmann-La Roche Ltd.; Novartis International AG; Pfizer, Inc.; and Sanofi-Aventis, Paris, France. Dr. Capponi has received consulting fees and honoraria from F. Hoffmann-La Roche Ltd. Dr. Burgess is an employee of Hoffmann-La Roche Inc., Nutley, New Jersey. Drs. Niesor and Kallend are employees of F. Hoffmann-La Roche Ltd. Dr. Kastelein has received research grants, honoraria, or consulting fees for professional input and/or has delivered lectures for Pfizer, Inc.; Merck Sharp & Dohme; F. Hoffmann-La Roche Ltd.; Novartis International AG; Isis Pharmaceuticals, Inc.; Kowa Pharmaceutical Company Ltd., Nagoya, Japan; Schering-Plough Corporation; and AstraZeneca.","year":2009,"lang":"en","type":"article","venue":"The American Journal of Cardiology","topic":"Pharmacology and Obesity Treatment","field":"Medicine","cited_by":137,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital; University of Toronto","funders":"","keywords":"Medicine; Cholesterylester transfer protein; Pharmacology; Tolerability; Aldosterone; Internal medicine; Aldosterone synthase; Placebo; Adverse effect; Atorvastatin; Endocrinology; Cholesterol; Blood pressure; Renin–angiotensin system; Lipoprotein; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000983485,0.0004074207,0.0008036803,0.0002037793,0.0002126311,0.0006633448,0.0002056547,0.0004069832,0.00504137],"category_scores_gemma":[0.002267045,0.0001231388,0.0008189318,0.000259698,0.0002515859,0.0003144011,0.0001752802,0.001092741,0.001132208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006519358,"about_ca_system_score_gemma":0.0008582188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001404848,"about_ca_topic_score_gemma":0.001336286,"domain_scores_codex":[0.9993613,0.0002155035,0.00006676954,0.00007843835,0.0002092827,0.00006867611],"domain_scores_gemma":[0.9989324,0.0003249799,0.0002470564,0.00008256582,0.0002269591,0.0001860155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.2082934,0.005197294,0.0644262,0.002420802,0.001724494,0.0009780836,0.0004319335,0.002075275,0.0721236,0.0005694773,0.01175913,0.6300003],"study_design_scores_gemma":[0.03166171,0.2705939,0.5533531,0.000582205,0.003908029,0.0049498,0.0007583861,0.01053103,0.07638656,0.001171598,0.04587948,0.0002243652],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.964726,0.01755424,0.00186044,0.001788458,0.0002179087,0.0003468463,0.003104683,0.0002120878,0.01018935],"genre_scores_gemma":[0.9949875,0.001674193,0.000359485,0.0003225013,0.0001008853,0.00005637296,0.0008877952,0.0000235169,0.001587764],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.00504137,"threshold_uncertainty_score":0.01686502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.156122537219245,"score_gpt":0.3774624182483624,"score_spread":0.2213398810291174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}