{"id":"W2156361395","doi":"10.1038/msb.2010.61","title":"Modeling genome‐wide replication kinetics reveals a mechanism for regulation of replication timing","year":2010,"lang":"en","type":"article","venue":"Molecular Systems Biology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":132,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; American Cancer Society","keywords":"Replication (statistics); Replication timing; Biology; Origin of replication; Minichromosome maintenance; Computational biology; Origin recognition complex; Mechanism (biology); DNA replication; Minichromosome; Genome; Chromatin; Genetics; DNA; Eukaryotic DNA replication; Gene; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009378028,0.0005042682,0.0005709262,0.0004225236,0.0003019736,0.0008034632,0.0008090205,0.0008631763,0.0004310951],"category_scores_gemma":[0.002906115,0.0005912512,0.0007544211,0.0004681973,0.0005385887,0.0009857786,0.000329089,0.0006710396,0.0001961716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001057877,"about_ca_system_score_gemma":0.0007777847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005565054,"about_ca_topic_score_gemma":0.003980298,"domain_scores_codex":[0.9997464,0.00007351994,0.00001316976,0.0000950432,0.00004063419,0.00003117091],"domain_scores_gemma":[0.9992423,0.0005158105,0.0001176218,0.00006359152,0.00003728419,0.00002347149],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00004432977,0.000022594,0.002695601,0.00003225982,0.00003252404,0.00003520992,0.00005891325,0.9695441,0.01728261,0.00699203,0.00007115884,0.003188735],"study_design_scores_gemma":[0.000004637034,0.00001120964,0.0008332398,0.000001464169,0.00000708276,0.00001376085,0.000005366603,0.9950042,0.001117222,0.002867047,0.0001283754,0.000006391782],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5476278,0.0003964419,0.4496199,0.0004083405,0.00001944161,0.00003149311,0.0001683174,0.0003481041,0.00138007],"genre_scores_gemma":[0.9781913,0.0003261243,0.02022749,0.000036575,0.000011361,0.00005740292,0.0001162996,0.00005105448,0.0009823841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005565054,"threshold_uncertainty_score":0.0110653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01801413166576629,"score_gpt":0.2712470660161777,"score_spread":0.2532329343504114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}