{"id":"W2156361395","doi":"10.1038/msb.2010.61","title":"Modeling genome‐wide replication kinetics reveals a mechanism for regulation of replication timing","year":2010,"lang":"en","type":"article","venue":"Molecular Systems Biology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":132,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; American Cancer Society","keywords":"Replication (statistics); Replication timing; Biology; Origin of replication; Minichromosome maintenance; Computational biology; Origin recognition complex; Mechanism (biology); DNA replication; Minichromosome; Genome; Chromatin; Genetics; DNA; Eukaryotic DNA replication; Gene; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008234031,0.0001952448,0.0002777807,0.0001017337,0.00006160001,0.0000157345,0.0002955298,0.0004800729,0.000002791574],"category_scores_gemma":[0.0008459979,0.000205892,0.0001393336,0.0001022197,0.00004173585,0.000004860872,0.00009210773,0.00009411002,0.000003185747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002159529,"about_ca_system_score_gemma":0.00004019267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003245402,"about_ca_topic_score_gemma":0.0000108514,"domain_scores_codex":[0.998044,0.0001180531,0.0006092158,0.0008514472,0.0001061402,0.0002711919],"domain_scores_gemma":[0.9971799,0.0000206624,0.0003507131,0.001865035,0.0005145253,0.00006912413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000366681,0.00003138849,0.0000729688,0.00006598105,0.00004319153,2.265105e-7,0.00001866868,0.001180098,0.9634882,0.03460626,0.00002005719,0.000436244],"study_design_scores_gemma":[0.0003547353,0.0003544686,0.00007079527,0.00001744034,0.00003940346,0.00002847572,0.0000197012,0.05493544,0.9370649,0.005701312,0.00119311,0.0002201513],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5248563,0.0001201406,0.4738693,0.00006960256,0.0002200972,0.0007010064,0.00002300251,0.00002539962,0.0001151889],"genre_scores_gemma":[0.9802023,0.00001445898,0.01807643,0.0001175217,0.0001715828,0.0003567834,0.0008266207,0.00005241218,0.0001818568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4557929,"threshold_uncertainty_score":0.8396031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01801413166576629,"score_gpt":0.2712470660161777,"score_spread":0.2532329343504114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}