{"id":"W2156445500","doi":"10.1136/ard.2004.030429","title":"Proteolysis of serum amyloid A and AA amyloid proteins by cysteine proteases: cathepsin B generates AA amyloid proteins and cathepsin L may prevent their formation","year":2005,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":false,"ca_institutions":"Biotechnology Research Institute","funders":"Deutsche Forschungsgemeinschaft","keywords":"Serum amyloid A; Cathepsin B; Amyloidosis; Serum Amyloid A Protein; Amyloid (mycology); Proteases; AA amyloidosis; Amyloid disease; Cathepsin; Proteolysis; Biochemistry; Amyloid precursor protein; Chemistry; Biology; Medicine; Pathology; Alzheimer's disease; Immunology; Amyloid β; Inflammation; Enzyme; Amyloid fibril; Familial Mediterranean fever; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003653062,0.0005537965,0.0007059018,0.0001188859,0.0002278658,0.00007399165,0.0004681938,0.000172271,0.00003378269],"category_scores_gemma":[0.0004074289,0.0003783681,0.0003383695,0.0002313949,0.0004005926,0.00007679558,0.0003691272,0.0001060937,0.000004214834],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003362538,"about_ca_system_score_gemma":0.0001559712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002414777,"about_ca_topic_score_gemma":0.0001075867,"domain_scores_codex":[0.9972528,0.0003654342,0.0009040351,0.0005740098,0.0004140085,0.0004896984],"domain_scores_gemma":[0.9976019,0.00006755591,0.0009182845,0.0009379297,0.0002333985,0.0002409474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001351743,0.01049071,0.07010631,0.007734767,0.004297934,0.000005166713,0.005105671,0.0006642998,0.6968383,0.000343312,0.0119531,0.1911088],"study_design_scores_gemma":[0.001430522,0.0009266715,0.01479344,0.0008612474,0.0002914358,0.00002081865,0.0004393637,0.000373186,0.9785399,0.0003336114,0.001481565,0.0005082058],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9756888,0.01460585,0.0001556135,0.003608487,0.00002816926,0.004587408,0.001255458,0.0000340336,0.0000361655],"genre_scores_gemma":[0.9925995,0.00354713,0.0008902873,0.0002926228,0.00005735888,0.001823052,0.0001473697,0.00006512869,0.0005775791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2817017,"threshold_uncertainty_score":0.9998668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01486709042742237,"score_gpt":0.2592062010171348,"score_spread":0.2443391105897124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}