{"id":"W2156445500","doi":"10.1136/ard.2004.030429","title":"Proteolysis of serum amyloid A and AA amyloid proteins by cysteine proteases: cathepsin B generates AA amyloid proteins and cathepsin L may prevent their formation","year":2005,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":false,"ca_institutions":"Biotechnology Research Institute","funders":"Deutsche Forschungsgemeinschaft","keywords":"Serum amyloid A; Cathepsin B; Amyloidosis; Serum Amyloid A Protein; Amyloid (mycology); Proteases; AA amyloidosis; Amyloid disease; Cathepsin; Proteolysis; Biochemistry; Amyloid precursor protein; Chemistry; Biology; Medicine; Pathology; Alzheimer's disease; Immunology; Amyloid β; Inflammation; Enzyme; Amyloid fibril; Familial Mediterranean fever; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007810318,0.0003195251,0.000379972,0.0004259213,0.0001723197,0.000586705,0.0001471966,0.0004993032,0.001004656],"category_scores_gemma":[0.001217026,0.0001220656,0.0003828932,0.000197744,0.0002384462,0.0003051528,0.0002222663,0.0004745604,0.0002988107],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000431068,"about_ca_system_score_gemma":0.0003829713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004757944,"about_ca_topic_score_gemma":0.0003317369,"domain_scores_codex":[0.9997519,0.00008503503,0.00003121031,0.00002740258,0.00005712984,0.00004735504],"domain_scores_gemma":[0.9995331,0.0001253339,0.0001315542,0.00003971986,0.00007443882,0.00009584915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008631421,0.0009353691,0.1110057,0.000619164,0.0004509465,0.004317688,0.0002833112,0.0005204112,0.7587731,0.002138578,0.002701314,0.1096231],"study_design_scores_gemma":[0.0006718125,0.004088714,0.2290566,0.00008848136,0.0003989874,0.02825269,0.0002505925,0.002533025,0.715384,0.002642723,0.01658705,0.00004521509],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979477,0.01299493,0.003061703,0.001015434,0.00009632087,0.00004642358,0.0001187867,0.0001120449,0.003077449],"genre_scores_gemma":[0.9970365,0.001197336,0.0007915173,0.0001015031,0.00003594349,0.0000112608,0.00007172785,0.000005631608,0.0007486338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001004656,"threshold_uncertainty_score":0.004130542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01486709042742237,"score_gpt":0.2592062010171348,"score_spread":0.2443391105897124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}