{"id":"W2156458610","doi":"10.1287/opre.1070.0480","title":"The Optimal Time to Initiate HIV Therapy Under Ordered Health States","year":2008,"lang":"en","type":"article","venue":"Operations Research","topic":"HIV/AIDS Research and Interventions","field":"Medicine","cited_by":155,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute on Alcohol Abuse and Alcoholism; National Institutes of Health; National Science Foundation","keywords":"Human immunodeficiency virus (HIV); Intensive care medicine; Markov decision process; Risk analysis (engineering); Medicine; Computer science; Quality (philosophy); Antiretroviral therapy; Markov process; Immunology; Viral load; Mathematics; Epistemology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.001485113,0.0001031977,0.0001714656,0.0003112743,0.002362762,0.0001810938,0.0002564359,0.00004171707,0.004328511],"category_scores_gemma":[0.0004768744,0.00006649888,0.00008633663,0.0008829763,0.0003271905,0.0001429197,0.0001111175,0.0005389136,0.00745625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001756923,"about_ca_system_score_gemma":0.001237782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007540027,"about_ca_topic_score_gemma":0.0003605832,"domain_scores_codex":[0.9972744,0.0005709651,0.0003032069,0.000261613,0.0008581844,0.0007316186],"domain_scores_gemma":[0.997844,0.0002515254,0.000009635555,0.0004966633,0.0009146369,0.0004835493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003195835,0.0005283775,0.0001197919,0.00001286023,0.0001226734,0.00003140609,0.001809006,0.001401692,0.003895826,0.001332873,0.9708622,0.01956371],"study_design_scores_gemma":[0.003746281,0.01416881,0.004915071,0.0002124765,0.000005270088,0.0002110408,0.002769099,0.08077228,0.003541489,0.0002776104,0.8890519,0.0003286873],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.5491502,0.003829049,0.01779338,0.3619699,0.00005840509,0.005758668,0.0002750353,0.0002091337,0.06095619],"genre_scores_gemma":[0.2647642,0.005898944,0.002516001,0.001449987,0.0002476742,0.0006657456,0.0003686204,0.0000592226,0.7240295],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.6630734,"threshold_uncertainty_score":0.998936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.148691597856198,"score_gpt":0.4715894773964985,"score_spread":0.3228978795403005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}