{"id":"W2156459362","doi":"10.1038/ng.873","title":"Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility","year":2011,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":907,"is_retracted":false,"has_abstract":false,"ca_institutions":"Memorial University of Newfoundland; University of Alberta; University of Toronto","funders":"National Health and Medical Research Council; Canadian Institutes of Health Research; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Medical Research Council; Versus Arthritis; Karolinska Institutet; Arthritis Society; Stiftelsen för Strategisk Forskning; Knut och Alice Wallenbergs Stiftelse; Australian Cancer Research Foundation; National Center for Research Resources; Ontario Genomics Institute; Università di Cagliari; National Institute for Health and Care Research; National Institutes of Health; Ontario Genomics; Genome Canada; GlaxoSmithKline; Cedars-Sinai Medical Center; Ontario Innovation Trust; Lions Medical Research Foundation; Wellcome Trust","keywords":"Ankylosing spondylitis; HLA-B27; Human leukocyte antigen; Biology; Immunology; Disease; Mechanism (biology); Spondylitis; Genetics; Medicine; Antigen; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003990394,0.0002600513,0.0002790779,0.0003000397,0.000216167,0.0003705268,0.0003591332,0.0004663068,0.003730148],"category_scores_gemma":[0.0005986585,0.0002676892,0.0002788263,0.00015345,0.0002878573,0.0002782898,0.0003681525,0.000689531,0.000592171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000228332,"about_ca_system_score_gemma":0.0001874697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000267665,"about_ca_topic_score_gemma":0.0002318634,"domain_scores_codex":[0.9997855,0.00006664046,0.00001524382,0.00004023342,0.00004384369,0.00004852244],"domain_scores_gemma":[0.9997099,0.0001203153,0.0000705561,0.00003411831,0.00001801546,0.0000471237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001444076,0.0001013621,0.01884443,0.00013035,0.0001625078,0.003049573,0.0001342445,0.000605773,0.9563568,0.002135356,0.0007137679,0.01632171],"study_design_scores_gemma":[0.0004688351,0.001779121,0.3173279,0.0000813841,0.0004104774,0.02796779,0.0004172779,0.009367688,0.621404,0.006459853,0.01424913,0.00006656348],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925147,0.0033157,0.001507556,0.000511717,0.00004481414,0.000005537322,0.000120685,0.00004877327,0.001930416],"genre_scores_gemma":[0.9975564,0.0004754974,0.0005242726,0.00006887462,0.00002193136,0.000005350399,0.00008069701,0.00001093441,0.001255966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003730148,"threshold_uncertainty_score":0.01247859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03268966452519435,"score_gpt":0.3122260787101829,"score_spread":0.2795364141849886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}