{"id":"W2156476753","doi":"10.1016/j.aca.2013.11.014","title":"Liquid chromatography tandem mass spectrometry determination of free and conjugated estrogens in breast cancer patients before and after exemestane treatment","year":2013,"lang":"en","type":"article","venue":"Analytica Chimica Acta","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; U.S. Food and Drug Administration","keywords":"Chemistry; Exemestane; Estrogen; Urine; Aromatase; Chromatography; Breast cancer; Urinary system; Endocrinology; Free fraction; Internal medicine; Detection limit; Cancer; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002023445,0.0002034625,0.0005680058,0.0008703077,0.0003374277,0.0004411099,0.0001446697,0.0004631683,0.000590241],"category_scores_gemma":[0.0008333189,0.0001748463,0.0002986584,0.0005583232,0.0001608282,0.0001654603,0.0001173231,0.0004750476,0.0001777202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000351202,"about_ca_system_score_gemma":0.0003512465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00272236,"about_ca_topic_score_gemma":0.003082067,"domain_scores_codex":[0.9997445,0.00005106194,0.00003240752,0.00004729191,0.00008322657,0.00004151318],"domain_scores_gemma":[0.9996604,0.0001170219,0.00007421047,0.00001389013,0.00006535518,0.00006916194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01010068,0.0003815629,0.9104267,0.00007518104,0.0002757408,0.001086795,0.0003130575,0.0002589229,0.05493435,0.00005636268,0.0003308155,0.02175989],"study_design_scores_gemma":[0.00006521797,0.001143791,0.9860731,0.00001062324,0.0001859697,0.001500122,0.0002818447,0.0006307521,0.009212891,0.00004802487,0.0008319463,0.0000156281],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980654,0.001178437,0.0000876633,0.00004690685,0.00001761942,0.000006782902,0.0001793034,0.000007318017,0.0004105919],"genre_scores_gemma":[0.9986097,0.0003088709,0.0001362983,0.00008353424,0.00001644287,0.00001002805,0.0002051935,0.000002438105,0.0006274916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00272236,"threshold_uncertainty_score":0.005413055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002575954072531157,"score_gpt":0.2090249675782248,"score_spread":0.2064490135056937,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}