{"id":"W2156520838","doi":"10.1158/1078-0432.ccr-09-1993","title":"An Overview of the Optimal Planning, Design, and Conduct of Phase I Studies of New Therapeutics","year":2010,"lang":"en","type":"review","venue":"Clinical Cancer Research","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":118,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Clinical trial; Clinical study design; Medicine; Drug development; Research design; Clinical endpoint; Medical physics; Drug; Pharmacology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"not_applicable","genre":"review","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"},{"model":"gpt","categories":["metaresearch"],"domain":"methods","study_design":"design_other","genre":"review","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"}],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","sts","research_integrity"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.03320581,0.0003773843,0.00548572,0.0001338656,0.00007898638,0.00001808178,0.001491653,0.0008767074,0.0001991548],"category_scores_gemma":[0.1203331,0.0002098057,0.0007621432,0.0006559658,0.00413672,0.0000430292,0.0006582412,0.002849394,0.000001490557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004502988,"about_ca_system_score_gemma":0.002163267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003002148,"about_ca_topic_score_gemma":0.000004540398,"domain_scores_codex":[0.9813488,0.01205895,0.004265347,0.0006666847,0.001218934,0.0004413501],"domain_scores_gemma":[0.7522355,0.2423652,0.002223738,0.001728344,0.00116029,0.0002869305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003096512,0.0006902164,0.00002030893,0.02477552,0.0009746096,0.000003098846,0.000170928,6.316899e-7,0.00001994463,0.006049582,0.001679957,0.9653056],"study_design_scores_gemma":[0.004129404,0.006019283,0.00001732711,0.05683863,0.004925226,0.000006870379,0.0002002567,0.00006467158,0.0006113243,0.4419811,0.4846162,0.0005897561],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005153859,0.9945278,0.001669589,0.00008698593,0.0006655566,0.002213573,0.0002786053,0.00001058526,0.00003188752],"genre_scores_gemma":[0.0000142213,0.8207671,0.1785413,0.00002349195,0.0004021041,0.00008085727,9.475081e-7,0.00006240941,0.0001075058],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9647158,"threshold_uncertainty_score":0.9994511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.9926679819552562,"score_gpt":0.8542575059713408,"score_spread":0.1384104759839154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}