{"id":"W2156587901","doi":"10.1074/jbc.m109.068486","title":"Biochemical Characterization of κM-RIIIJ, a Kv1.2 Channel Blocker","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of General Medical Sciences","keywords":"Conotoxin; Conus; Xenopus; Potassium channel; Scorpion Venoms; Venom; Pharmacology; In vivo; Chemistry; Ion channel; Potassium channel blocker; Biology; Potency; Sodium channel; Protein subunit; Biochemistry; Biophysics; In vitro; Anatomy; Receptor; Sodium; Scorpion","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002035884,0.0003413448,0.0003350251,0.0001552751,0.0001741736,0.000284281,0.0002562724,0.0002261293,0.001170706],"category_scores_gemma":[0.0002556418,0.0001188399,0.0003687105,0.0001590617,0.0001191644,0.0001635866,0.00009333398,0.000437477,0.0006867177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003298073,"about_ca_system_score_gemma":0.0002999545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008969897,"about_ca_topic_score_gemma":0.0008596882,"domain_scores_codex":[0.9998497,0.00001730599,0.00001731175,0.00003144138,0.00004821216,0.00003613012],"domain_scores_gemma":[0.9998478,0.00001891912,0.00004009902,0.00001443089,0.00003602662,0.0000427974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004447838,0.00001775033,0.00007848846,0.00002539165,0.000004665548,0.00004221869,0.000006561056,0.00005503746,0.999136,0.0000237085,0.00002128971,0.0005444335],"study_design_scores_gemma":[0.00002876594,0.0004204629,0.004532532,0.000007995741,0.00003203541,0.0006617561,0.0000207733,0.0007986475,0.9897715,0.00002380043,0.003693549,0.000007991473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9767631,0.005205096,0.01166546,0.0002999474,0.00007525134,0.000159156,0.001371418,0.0001239436,0.004336522],"genre_scores_gemma":[0.966927,0.004048414,0.01496396,0.0002735778,0.00006147837,0.00009948727,0.006621437,0.00008262601,0.006922039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001170706,"threshold_uncertainty_score":0.003916383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01061806641163623,"score_gpt":0.2486424498197569,"score_spread":0.2380243834081207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}