{"id":"W2156603613","doi":"10.7554/elife.02935","title":"Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer","year":2014,"lang":"en","type":"article","venue":"eLife","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":500,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"NIHR Cambridge Biomedical Research Centre; National Institutes of Health; Institut Bergonié; Universitetet i Oslo; King's College London; Lunds Universitet; Blood Cancer UK; British Lung Foundation; Erasmus Medisch Centrum; National Cancer Institute; King's Health Partners; Chordoma Foundation; Institut National de la Santé et de la Recherche Médicale; Leukemia and Lymphoma Society; Leukaemia and Lymphoma Research; European Molecular Biology Organization; Medical Research Council; Department of Health and Social Care; University of Cambridge; National Institute of Environmental Health Sciences; Kay Kendall Leukaemia Fund; Cancer Research UK; Wellcome Trust; Skånes universitetssjukhus; National Cancer Research Institute; University College London Hospitals NHS Foundation Trust; European Commission; Adenoid Cystic Carcinoma Research Foundation; National Institute for Health and Care Research; Wellcome; Brigham and Women's Hospital","keywords":"Somatic cell; Mitochondrial DNA; Biology; Genetics; Cancer; DNA; Human mitochondrial genetics; Mutation; DNA damage; Mitochondrion; Human genome; Genome; Evolutionary biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002228796,0.00008191285,0.0001297249,0.0007766288,0.0001637322,0.0002065111,0.0001235211,0.0001689015,0.0006396775],"category_scores_gemma":[0.0005693576,0.00005558495,0.00009500183,0.0004407403,0.0002844843,0.000090151,0.000181273,0.0001161586,0.000120001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000206086,"about_ca_system_score_gemma":0.0001183299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005888506,"about_ca_topic_score_gemma":0.001329311,"domain_scores_codex":[0.9998289,0.00003358007,0.00001982728,0.00004432256,0.00004759844,0.00002577611],"domain_scores_gemma":[0.9997124,0.00007164886,0.000119394,0.00002720337,0.00003378635,0.00003547119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000630148,0.00003821048,0.6372803,0.0001628836,0.0001168442,0.001958762,0.000329391,0.0006140798,0.3306628,0.0005283324,0.0001030502,0.02757516],"study_design_scores_gemma":[0.00000902971,0.0001747934,0.9446003,0.00001934047,0.00008368837,0.007904874,0.0002435862,0.001020356,0.04405906,0.0004192359,0.001456755,0.000008920171],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980141,0.001248985,0.0003087529,0.00001604392,0.000002005204,0.000002803204,0.0001246265,0.000004989589,0.0002777013],"genre_scores_gemma":[0.9993104,0.0003053282,0.0002054727,0.000006813712,0.000002225954,0.000001091477,0.00009788123,0.000002051157,0.00006876567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007766288,"threshold_uncertainty_score":0.002139926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01770718428188655,"score_gpt":0.2775557098980623,"score_spread":0.2598485256161758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}