{"id":"W2156603613","doi":"10.7554/elife.02935","title":"Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer","year":2014,"lang":"en","type":"article","venue":"eLife","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":500,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"NIHR Cambridge Biomedical Research Centre; National Institutes of Health; Institut Bergonié; Universitetet i Oslo; King's College London; Lunds Universitet; Blood Cancer UK; British Lung Foundation; Erasmus Medisch Centrum; National Cancer Institute; King's Health Partners; Chordoma Foundation; Institut National de la Santé et de la Recherche Médicale; Leukemia and Lymphoma Society; Leukaemia and Lymphoma Research; European Molecular Biology Organization; Medical Research Council; Department of Health and Social Care; University of Cambridge; National Institute of Environmental Health Sciences; Kay Kendall Leukaemia Fund; Cancer Research UK; Wellcome Trust; Skånes universitetssjukhus; National Cancer Research Institute; University College London Hospitals NHS Foundation Trust; European Commission; Adenoid Cystic Carcinoma Research Foundation; National Institute for Health and Care Research; Wellcome; Brigham and Women's Hospital","keywords":"Somatic cell; Mitochondrial DNA; Biology; Genetics; Cancer; DNA; Human mitochondrial genetics; Mutation; DNA damage; Mitochondrion; Human genome; Genome; Evolutionary biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007017187,0.00006599427,0.0001037009,0.00004551988,0.00004404377,0.000005793964,0.00003750365,0.00007876323,0.0001184814],"category_scores_gemma":[0.00009990803,0.00006200778,0.00002674297,0.00004944611,0.0001359788,0.000002484033,0.00001792165,0.00004397667,0.000004260573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009190077,"about_ca_system_score_gemma":0.00005758808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001323188,"about_ca_topic_score_gemma":0.0004582118,"domain_scores_codex":[0.9994436,0.000066694,0.0001664,0.0001609492,0.00007348121,0.00008891032],"domain_scores_gemma":[0.9997381,0.0000197455,0.00005823218,0.0001013425,0.00004571263,0.00003687564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000280564,0.00001968638,0.007130335,0.00001018562,0.000009864134,4.051628e-7,0.00004482814,0.0001017197,0.9882916,0.003525255,0.0007009609,0.0001371386],"study_design_scores_gemma":[0.00192059,0.0003437265,0.02636437,0.00003060269,0.00002704975,0.00002191561,0.0001053535,0.00008529368,0.9285911,0.001133085,0.04115929,0.0002176402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961134,0.0001193528,0.002207085,0.0001885532,0.0005755306,0.00009184211,0.00001390601,0.000005172139,0.0006851461],"genre_scores_gemma":[0.998341,0.00003178305,0.0005581211,0.0002222353,0.0004163429,0.00003119906,0.00006078286,0.000005732595,0.0003328283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05970048,"threshold_uncertainty_score":0.2528604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01770718428188655,"score_gpt":0.2775557098980623,"score_spread":0.2598485256161758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}