{"id":"W2156613610","doi":"10.1016/j.cell.2008.02.043","title":"Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury","year":2008,"lang":"en","type":"article","venue":"Cell","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":1356,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital; University of Toronto; Lawson Health Research Institute; Western University","funders":"Defense Threat Reduction Agency; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Canadian Institutes of Health Research; European Commission; University of Pittsburgh","keywords":"TRIF; TLR4; Oxidative stress; Biology; Immunology; Innate immune system; Influenza A virus subtype H5N1; Lung; Toll-like receptor; Receptor; Signal transduction; Inflammation; Immune system; Medicine; Cell biology; Internal medicine; Virus; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005528885,0.0006554686,0.0004170467,0.0009037601,0.0004138965,0.0006788976,0.0004880662,0.0006295639,0.002178284],"category_scores_gemma":[0.0002139355,0.000213263,0.0003595873,0.0003569361,0.0006339795,0.0009419777,0.0006003644,0.0009455028,0.0004354213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004650475,"about_ca_system_score_gemma":0.0005221701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003188271,"about_ca_topic_score_gemma":0.0003192076,"domain_scores_codex":[0.9998067,0.00004291371,0.00001699583,0.00002626362,0.00005317661,0.00005394817],"domain_scores_gemma":[0.9998356,0.00002290973,0.00004094665,0.00001477356,0.00003986663,0.00004581414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002514787,0.0002547716,0.004543343,0.0003938994,0.00005023237,0.001197997,0.00007797107,0.0001918731,0.9653732,0.003285884,0.0006285229,0.02148772],"study_design_scores_gemma":[0.0002867946,0.002483729,0.07560813,0.0001148985,0.0002618651,0.006133053,0.0005651111,0.003339059,0.8810966,0.008514483,0.02155023,0.00004600452],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9355983,0.03902678,0.01498107,0.003205435,0.0005075088,0.0001309769,0.000568966,0.0001225103,0.005858558],"genre_scores_gemma":[0.9743798,0.0123376,0.006515019,0.0004877472,0.000414311,0.0001144107,0.0006647519,0.000009035336,0.005077395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002178284,"threshold_uncertainty_score":0.007287085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006945992174811727,"score_gpt":0.2239649093635281,"score_spread":0.2170189171887163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}