{"id":"W2156636883","doi":"10.1158/1078-0432.ccr-13-1856","title":"Novel <i>MSH6</i> Mutations in Treatment-Naïve Glioblastoma and Anaplastic Oligodendroglioma Contribute to Temozolomide Resistance Independently of <i>MGMT</i> Promoter Methylation","year":2014,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Calgary","funders":"Stem Cell Network; American Association for Cancer Research","keywords":"Temozolomide; MSH6; Glioma; Cancer research; Oligodendroglioma; Biology; Methyltransferase; Medicine; Methylation; DNA repair; DNA mismatch repair; Genetics; Astrocytoma; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001473792,0.0001769406,0.0002298716,0.0003282314,0.0001868679,0.0002214255,0.0001470654,0.000224337,0.0007758182],"category_scores_gemma":[0.0002994527,0.000121291,0.0001380424,0.0002040393,0.0002099555,0.00008810442,0.00009934239,0.0002131886,0.0001510973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003332943,"about_ca_system_score_gemma":0.0001849398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001708328,"about_ca_topic_score_gemma":0.002746558,"domain_scores_codex":[0.9998763,0.00001586067,0.00001691496,0.00003224875,0.00003670692,0.00002201129],"domain_scores_gemma":[0.9998397,0.00002502912,0.00006281588,0.00001309772,0.00002087505,0.00003854879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001436856,0.0001449726,0.1853342,0.00007476638,0.00006854985,0.001601462,0.000197286,0.0002027042,0.801591,0.00007408055,0.0001403293,0.009133714],"study_design_scores_gemma":[0.00006626111,0.001545106,0.8454214,0.00000790913,0.0001175295,0.01092161,0.0001682357,0.000687068,0.1400405,0.00006971111,0.0009457318,0.00000899352],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995664,0.0001676603,0.00006418127,0.000006123686,0.000001123476,0.000005335757,0.00004174353,0.000005299811,0.0001421394],"genre_scores_gemma":[0.9996114,0.00007147239,0.0001147001,0.000008918074,0.000001801251,0.000003438434,0.0001163253,0.000001794517,0.00007003773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001708328,"threshold_uncertainty_score":0.003396749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09377303030076796,"score_gpt":0.4504224624468205,"score_spread":0.3566494321460526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}