{"id":"W2156636883","doi":"10.1158/1078-0432.ccr-13-1856","title":"Novel <i>MSH6</i> Mutations in Treatment-Naïve Glioblastoma and Anaplastic Oligodendroglioma Contribute to Temozolomide Resistance Independently of <i>MGMT</i> Promoter Methylation","year":2014,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Calgary","funders":"Stem Cell Network; American Association for Cancer Research","keywords":"Temozolomide; MSH6; Glioma; Cancer research; Oligodendroglioma; Biology; Methyltransferase; Medicine; Methylation; DNA repair; DNA mismatch repair; Genetics; Astrocytoma; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001790055,0.0002058199,0.0007339095,0.0005104347,0.0001017164,0.00004098019,0.0001278564,0.0001915062,0.0000414118],"category_scores_gemma":[0.002038105,0.0001654226,0.0001264457,0.0009769649,0.000286611,0.0001021214,0.00009791373,0.0003473919,0.00002964225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003485795,"about_ca_system_score_gemma":0.0002872339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007371678,"about_ca_topic_score_gemma":0.01214707,"domain_scores_codex":[0.9968846,0.0003719269,0.0008558274,0.0006559753,0.0006995202,0.0005321056],"domain_scores_gemma":[0.996031,0.002376531,0.0001424657,0.0004417772,0.0005687511,0.0004394439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01670894,0.008979059,0.7949429,0.0005932593,0.0009638724,0.0004981871,0.001206745,0.0003143983,0.07764617,0.003041229,0.002689433,0.09241581],"study_design_scores_gemma":[0.03478139,0.01389132,0.8013629,0.001401563,0.0003860082,0.00005454608,0.0002298797,0.001429736,0.1334905,0.001411419,0.01106823,0.0004925427],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992995,0.0006938084,0.0002026822,0.003840156,0.0001105798,0.001454183,0.000131191,0.00002301686,0.0005493964],"genre_scores_gemma":[0.9977152,0.0002826378,0.0007762114,0.0001801636,0.0001498366,0.0005571535,0.00002209555,0.00003117771,0.0002855193],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09192327,"threshold_uncertainty_score":0.6778351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09377303030076796,"score_gpt":0.4504224624468205,"score_spread":0.3566494321460526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}