{"id":"W2156646223","doi":"10.1002/chem.201303867","title":"A Pyrimidopyrimidine Janus‐AT Nucleoside with Improved Base‐Pairing Properties to both A and T within a DNA Duplex: The Stabilizing Effect of a Second Endocyclic Ring Nitrogen","year":2014,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Chongqing University of Arts and Sciences; Francis Crick Institute","keywords":"Duplex (building); Base pair; Janus; Chemistry; Oligonucleotide; DNA; Phosphoramidite; Nucleotide; Nucleic acid; Stereochemistry; Nucleoside; Context (archaeology); Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid; Base (topology); Pairing; Combinatorial chemistry; Biochemistry; Biology; Nanotechnology; Gene; Physics; Materials science; Mathematics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001002679,0.0001691239,0.0002684752,0.00009746228,0.0001504727,0.0002625606,0.0002233107,0.0001805892,0.0005140979],"category_scores_gemma":[0.0001508002,0.0001040371,0.0001354926,0.00009520815,0.0001420933,0.0001367736,0.0001509868,0.0002858129,0.0001435836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001940871,"about_ca_system_score_gemma":0.0001675449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003694285,"about_ca_topic_score_gemma":0.0005286938,"domain_scores_codex":[0.999934,0.00001296394,0.000004504521,0.00002025681,0.00001664479,0.00001161373],"domain_scores_gemma":[0.9999272,0.00001173335,0.00002034443,0.000006853217,0.00000774092,0.00002615814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001412639,0.00004057991,0.0001648722,0.0000600687,0.00000712611,0.0001223701,0.00002425116,0.001014578,0.9919593,0.0007806054,0.00005241764,0.005632512],"study_design_scores_gemma":[0.00003907241,0.000940988,0.0005475598,0.000004796805,0.00001952941,0.000379014,0.00001100274,0.004522753,0.9890626,0.00009527862,0.004365736,0.00001164515],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929404,0.000867284,0.00336334,0.0000426138,0.00003190534,0.00003414802,0.00003951719,0.00005978241,0.00262086],"genre_scores_gemma":[0.992778,0.000301061,0.005482807,0.0000226044,0.000009772198,0.0000161336,0.00005654218,0.00001139988,0.001321588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005140979,"threshold_uncertainty_score":0.001719773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006397785061073298,"score_gpt":0.1844562158428161,"score_spread":0.1780584307817428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}