{"id":"W2156654507","doi":"10.1128/mbio.00103-11","title":"Cryptococcus neoformans Requires a Functional Glycolytic Pathway for Disease but Not Persistence in the Host","year":2011,"lang":"en","type":"article","venue":"mBio","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Cryptococcus neoformans; Virulence; Cryptococcosis; Microbiology; Glycolysis; Biology; Phosphoenolpyruvate carboxykinase; Gluconeogenesis; Cryptococcus gattii; Mutant; Hexose; Cryptococcus; Biochemistry; Gene; Metabolism; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008226816,0.0003070576,0.0001863951,0.0001499021,0.0001282145,0.000301779,0.0001869531,0.0002713134,0.0008732532],"category_scores_gemma":[0.0001054183,0.0001034298,0.0001733926,0.0001142437,0.0002210001,0.0001507695,0.0002269451,0.0004104624,0.0001999675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003130569,"about_ca_system_score_gemma":0.0003272672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00189109,"about_ca_topic_score_gemma":0.001518321,"domain_scores_codex":[0.9998468,0.00001388178,0.00001390404,0.00002654449,0.00004323764,0.00005553977],"domain_scores_gemma":[0.9998391,0.0000204613,0.00004834093,0.00002125704,0.00001660794,0.0000542052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009716334,0.00004013848,0.0005881004,0.00001476864,0.00000196667,0.00007156325,0.000007466062,0.00004471681,0.9984722,0.00006658093,0.0000157308,0.0005796095],"study_design_scores_gemma":[0.00001765991,0.000512577,0.0271317,0.00001561109,0.00001066154,0.001059425,0.00009318336,0.001249109,0.9688697,0.00009494968,0.0009362894,0.000009157308],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985869,0.000145384,0.0005145871,0.00004228202,0.000006824433,0.0000088115,0.0002006104,0.00002350471,0.0004711673],"genre_scores_gemma":[0.9987179,0.00006640134,0.0005445622,0.00002042098,0.000001439442,0.000007393987,0.0001855496,0.000006050488,0.0004503903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00189109,"threshold_uncertainty_score":0.003760159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1215978709533813,"score_gpt":0.266772727681256,"score_spread":0.1451748567278746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}