{"id":"W2156657486","doi":"10.1084/jem.20081811","title":"CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance","year":2009,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":258,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases","keywords":"CTLA-4; Cytotoxic T cell; FOXP3; Biology; Cell biology; T cell; Immunology; Regulatory T cell; Interleukin 21; Antigen-presenting cell; Antigen; IL-2 receptor; Peripheral tolerance; Immune tolerance; Immune system; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001629095,0.0003576453,0.000235557,0.0001733629,0.0001306888,0.0003817522,0.0002692596,0.0003053396,0.001640473],"category_scores_gemma":[0.000200052,0.0001671501,0.0001653984,0.0001133973,0.0003784548,0.0002499822,0.000231285,0.0007516752,0.0008363306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000278662,"about_ca_system_score_gemma":0.0002942729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002238159,"about_ca_topic_score_gemma":0.0002102135,"domain_scores_codex":[0.9998479,0.00002462547,0.00001490348,0.0000336651,0.00003440003,0.00004450808],"domain_scores_gemma":[0.999805,0.00002411484,0.00006282137,0.0000432463,0.0000285508,0.00003627046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007101541,0.00002225707,0.0002339058,0.00001975215,0.000001987343,0.00004941008,0.000006195051,0.0000659081,0.9977296,0.0001570008,0.00002416532,0.001618814],"study_design_scores_gemma":[0.00006865507,0.0004742114,0.004070133,0.000009310037,0.00002527674,0.0007168324,0.00003022539,0.0009943921,0.9905019,0.000420575,0.002684223,0.00000439156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877006,0.001189,0.0072887,0.0001534239,0.00005140783,0.00003434597,0.0001624667,0.0002504007,0.003169703],"genre_scores_gemma":[0.9917031,0.0003746883,0.003874745,0.0000761983,0.00002580787,0.00003785705,0.0003514135,0.00003672329,0.003519552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001640473,"threshold_uncertainty_score":0.005487919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01415409096950756,"score_gpt":0.2585136456719309,"score_spread":0.2443595547024233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}