{"id":"W2156665587","doi":"10.1186/1868-7083-6-19","title":"Epigenetic therapy of acute myeloid leukemia using 5-aza-2'-deoxycytidine (decitabine) in combination with inhibitors of histone methylation and deacetylation","year":2014,"lang":"en","type":"article","venue":"Clinical Epigenetics","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal","funders":"Université de Montréal","keywords":"Trichostatin A; Decitabine; EZH2; Epigenetics; Epigenetic therapy; Cancer research; Biology; Gene silencing; Chromatin; DNA methylation; Acetylation; PRC2; Histone; Methylation; Histone deacetylase; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001887264,0.0002205204,0.0008181133,0.0003304115,0.00004281165,0.000008089339,0.0001236649,0.0003201469,0.00001940191],"category_scores_gemma":[0.0007074591,0.0001879201,0.0001069141,0.0005546637,0.000534185,0.00007583724,0.00007247271,0.0004212371,0.000002208489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003189945,"about_ca_system_score_gemma":0.0004761679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001777337,"about_ca_topic_score_gemma":0.0000228943,"domain_scores_codex":[0.9970232,0.0003779507,0.001366489,0.0004214064,0.0005291612,0.0002818477],"domain_scores_gemma":[0.9974965,0.0008357748,0.0005516916,0.0004672832,0.0004710132,0.0001777337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002755857,0.0008263197,0.5913442,0.0002788416,0.0003560412,0.00001186769,0.0006415872,0.002495531,0.2306993,0.0005033521,0.00003952538,0.1700476],"study_design_scores_gemma":[0.01213667,0.004516649,0.7598097,0.0003093435,0.0002163142,0.00001578736,0.00006326568,0.06667851,0.1546256,0.001092457,0.0002534965,0.0002821606],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9809177,0.0007736454,0.01706987,0.0002731712,0.00009873873,0.0007256091,0.000005917664,0.000018087,0.0001172611],"genre_scores_gemma":[0.978173,0.002993108,0.01851167,0.00007358562,0.000114035,0.000008875188,0.00003662435,0.00004778301,0.00004131369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1697654,"threshold_uncertainty_score":0.766316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05031231532236087,"score_gpt":0.3895590017751555,"score_spread":0.3392466864527947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}