{"id":"W2156665587","doi":"10.1186/1868-7083-6-19","title":"Epigenetic therapy of acute myeloid leukemia using 5-aza-2'-deoxycytidine (decitabine) in combination with inhibitors of histone methylation and deacetylation","year":2014,"lang":"en","type":"article","venue":"Clinical Epigenetics","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal","funders":"Université de Montréal","keywords":"Trichostatin A; Decitabine; EZH2; Epigenetics; Epigenetic therapy; Cancer research; Biology; Gene silencing; Chromatin; DNA methylation; Acetylation; PRC2; Histone; Methylation; Histone deacetylase; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001126487,0.0003112793,0.0003767467,0.000255722,0.0001373469,0.0001727792,0.0002407526,0.0001974019,0.001069488],"category_scores_gemma":[0.0001082693,0.00007702247,0.0001819499,0.000233271,0.0001246321,0.0001068949,0.0002302368,0.0004194787,0.0002434249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003260162,"about_ca_system_score_gemma":0.0002001676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006163624,"about_ca_topic_score_gemma":0.001537722,"domain_scores_codex":[0.9999192,0.00001585508,0.00000932302,0.000017984,0.00001881003,0.00001880373],"domain_scores_gemma":[0.9999672,0.000005514771,0.00001036145,0.000004562063,0.00000453365,0.000007839842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.001394032,0.0003344201,0.0007902543,0.0003185434,0.00007368034,0.0002433072,0.00005241987,0.000788331,0.8984331,0.0004378808,0.000509112,0.09662481],"study_design_scores_gemma":[0.0008132096,0.006172691,0.01212689,0.0000480803,0.0002566919,0.00234936,0.0000371102,0.002180581,0.9392369,0.000221479,0.03654325,0.00001369973],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9535289,0.03119247,0.006917601,0.0004799832,0.0002622633,0.0002898061,0.0004613038,0.0003244316,0.006543232],"genre_scores_gemma":[0.9884928,0.006003458,0.003026379,0.0001593305,0.00004275328,0.00009554866,0.0003678369,0.00001385673,0.001798032],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001069488,"threshold_uncertainty_score":0.003577769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05031231532236087,"score_gpt":0.3895590017751555,"score_spread":0.3392466864527947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}