{"id":"W2156666186","doi":"10.1038/ni1471","title":"Cell surface 4-1BBL mediates sequential signaling pathways 'downstream' of TLR and is required for sustained TNF production in macrophages","year":2007,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":112,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Western University","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Eye Institute","keywords":"TLR4; TRIF; Tumor necrosis factor alpha; Cell biology; Toll-like receptor; Stimulation; Lipopolysaccharide; Receptor; Cytokine; Transcription factor; Biology; Signal transduction; Immunology; Innate immune system; Endocrinology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001050948,0.0002178535,0.0004010072,0.0003019253,0.0001277736,0.000008337394,0.0001690791,0.001129406,0.00006120318],"category_scores_gemma":[0.0003764722,0.0002044815,0.00008483655,0.0002428841,0.0002981494,0.0001633053,0.00007254822,0.0006028208,0.00001295713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007235415,"about_ca_system_score_gemma":0.0001022109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005846994,"about_ca_topic_score_gemma":0.00002229511,"domain_scores_codex":[0.9983139,0.000208339,0.0005740945,0.0003681827,0.00004309927,0.0004923828],"domain_scores_gemma":[0.9988162,0.0003765146,0.0003007812,0.0002613518,0.0002331459,0.00001200793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002446522,0.0000897862,0.000492455,0.00008666646,0.0001102709,0.000007544912,0.001540869,0.000008548251,0.9895651,0.000445287,0.0003375561,0.004869343],"study_design_scores_gemma":[0.002242928,0.0003518735,0.003149942,0.00003928355,0.00003872352,0.00004824113,0.001499689,0.000004231656,0.9890694,0.0004635667,0.002909725,0.0001824085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9650979,0.03238753,0.0001399681,0.0005080655,0.001124258,0.0005513924,0.00002223015,0.00004594758,0.0001227211],"genre_scores_gemma":[0.9979768,0.0004922643,0.0004230249,0.00005382858,0.00005290743,0.00001232817,0.0001897672,0.00002204855,0.0007770775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03287886,"threshold_uncertainty_score":0.8711014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007381186230525865,"score_gpt":0.2419324503888689,"score_spread":0.2345512641583431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}