{"id":"W2156681099","doi":"10.1128/aac.02114-13","title":"Competitive Fitness Assays Indicate that the E138A Substitution in HIV-1 Reverse Transcriptase Decreases <i>In Vitro</i> Susceptibility to Emtricitabine","year":2014,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; University of British Columbia","funders":"National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Etravirine; Rilpivirine; Emtricitabine; Reverse transcriptase; Virology; Reverse-transcriptase inhibitor; Nucleoside Reverse Transcriptase Inhibitor; Tenofovir; Human immunodeficiency virus (HIV); Biology; Nucleoside; In vitro; Lamivudine; Virus; Genetics; RNA; Antiretroviral therapy; Viral load; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003585556,0.0006717229,0.0005887594,0.0001780474,0.000291497,0.0004949893,0.0006146272,0.0003480731,0.003357339],"category_scores_gemma":[0.0008390065,0.0002271603,0.0003569606,0.0003233865,0.0002075607,0.0002970978,0.0003469444,0.0008057303,0.00063193],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004802324,"about_ca_system_score_gemma":0.0003554935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004744963,"about_ca_topic_score_gemma":0.006069189,"domain_scores_codex":[0.9994462,0.0001051701,0.00005605143,0.0001101408,0.0002003773,0.00008212645],"domain_scores_gemma":[0.9994106,0.0001975523,0.0001073287,0.00008276116,0.0001398261,0.0000619075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001836147,0.0001245266,0.002934906,0.0000426563,0.00003540314,0.00004898388,0.00006659012,0.0006685091,0.9902881,0.0002194596,0.0001973036,0.00518996],"study_design_scores_gemma":[0.00002071019,0.0008658918,0.01071624,0.000006728911,0.00003834411,0.0004226053,0.00008082679,0.005480922,0.9803858,0.00009164004,0.001871231,0.00001912674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992702,0.0004645617,0.003072856,0.00009314132,0.00001857444,0.00003838303,0.001271149,0.00005952063,0.002279787],"genre_scores_gemma":[0.9900567,0.0002548588,0.005288176,0.00007179216,0.000009190027,0.00006783611,0.001818749,0.00006535267,0.002367351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004744963,"threshold_uncertainty_score":0.01123148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01445984829590002,"score_gpt":0.2473775569623198,"score_spread":0.2329177086664198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}