{"id":"W2156723868","doi":"10.1186/bcr1743","title":"The zinc finger domain of Wilms' tumor 1 suppressor gene (WT1) behaves as a dominant negative, leading to abrogation of WT1 oncogenic potential in breast cancer cells","year":2007,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Ontario Institute for Cancer Research","funders":"National Cancer Institute","keywords":"Surgical oncology; Zinc finger; Breast cancer; Wilms' tumor; Suppressor; Cancer research; Tumor suppressor gene; Gene; LIM domain; Cancer; Medicine; RING finger domain; Oncology; Biology; Internal medicine; Carcinogenesis; Transcription factor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001068464,0.0001794955,0.0002549822,0.0001860778,0.0001669101,0.00002623371,0.0004142173,0.0001567262,0.00008646971],"category_scores_gemma":[0.00002652453,0.0001310007,0.0001293119,0.0005366248,0.0003961453,0.00001173797,0.0002076506,0.0003071493,0.000007346765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002140443,"about_ca_system_score_gemma":0.0006016186,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009800132,"about_ca_topic_score_gemma":0.00250999,"domain_scores_codex":[0.9976569,0.0001841746,0.0004505143,0.000430389,0.000606693,0.0006713611],"domain_scores_gemma":[0.9988586,0.00006509627,0.0001605383,0.0002886393,0.0004621475,0.0001649982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002957381,0.00008629014,0.001288181,0.00005817125,0.0001040699,0.00002311844,0.0003046036,0.001103609,0.9858246,0.00002438982,0.0007452807,0.007480285],"study_design_scores_gemma":[0.00107042,0.0001640887,0.02285303,0.0002273235,0.0000197435,0.00006899207,0.0004462596,0.00002754497,0.973759,0.00006024913,0.001140323,0.000163035],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960639,0.001499495,0.00007160374,0.001098794,0.0001821992,0.0005062641,0.0002857005,0.00000341305,0.0002886184],"genre_scores_gemma":[0.9974788,0.001178014,0.0001092828,0.0000536618,0.00028666,0.000130498,0.00001062421,0.00003188698,0.0007205883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02156485,"threshold_uncertainty_score":0.9967937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01147461784102547,"score_gpt":0.3337746318780499,"score_spread":0.3223000140370244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}