{"id":"W2156728273","doi":"10.1002/jbmr.2382","title":"Novel EP4 Receptor Agonist-Bisphosphonate Conjugate Drug (C1) Promotes Bone Formation and Improves Vertebral Mechanical Properties in the Ovariectomized Rat Model of Postmenopausal Bone Loss","year":2014,"lang":"en","type":"article","venue":"Journal of Bone and Mineral Research","topic":"Bone health and treatments","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"","keywords":"Ovariectomized rat; Osteoporosis; Bone resorption; Internal medicine; Endocrinology; Bisphosphonate; Osteopenia; In vivo; Chemistry; Conjugate; Cortical bone; Agonist; Medicine; Resorption; Pharmacology; Receptor; Bone mineral; Estrogen; Anatomy; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001838987,0.0005363756,0.0005920096,0.0007155935,0.0001836586,0.0002048789,0.0003147796,0.0004801045,0.001386484],"category_scores_gemma":[0.00008722691,0.0001992705,0.0003748163,0.0003175469,0.0003021922,0.0003214142,0.0001641506,0.0009602957,0.0002303264],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000244864,"about_ca_system_score_gemma":0.0003705431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001008404,"about_ca_topic_score_gemma":0.002054444,"domain_scores_codex":[0.9998543,0.00001472325,0.0000117991,0.00002631858,0.00005185978,0.0000409261],"domain_scores_gemma":[0.9998989,0.000008462774,0.00003628477,0.000007434454,0.00001488405,0.00003408876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001732644,0.001087365,0.0002421509,0.000149544,0.00002295344,0.00009982261,0.00002419627,0.000160569,0.9905317,0.0001156708,0.0001101947,0.005723268],"study_design_scores_gemma":[0.0003273417,0.01380573,0.004220322,0.0000169875,0.00009637219,0.0002764847,0.0000524576,0.0007893616,0.9772456,0.00005807717,0.003097274,0.00001396075],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994509,0.002308183,0.001738913,0.0001518672,0.00005706704,0.00007913196,0.0003321878,0.00008394274,0.0007396355],"genre_scores_gemma":[0.9862679,0.003709285,0.003077276,0.0001184404,0.00003868827,0.0001510086,0.0007825657,0.00001902277,0.005835702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001386484,"threshold_uncertainty_score":0.004638255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05100561304900423,"score_gpt":0.3209231655624008,"score_spread":0.2699175525133966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}