{"id":"W2156744090","doi":"10.3201/eid2001.130858","title":"Molecular Barriers to Zoonotic Transmission of Prions","year":2013,"lang":"en","type":"article","venue":"Emerging infectious diseases","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Food Inspection Agency","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; University of Edinburgh","keywords":"Chronic wasting disease; Scrapie; Bovine spongiform encephalopathy; Virology; Disease; Prion protein; Pathogenesis; Biology; Gene isoform; Medicine; Immunology; Gene; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00104142,0.000289098,0.0003026832,0.0005356697,0.0002224673,0.00143419,0.0004860881,0.0006254632,0.001534159],"category_scores_gemma":[0.002194117,0.0002452507,0.0001599034,0.0001892275,0.0006788236,0.0008272345,0.0006809913,0.0006762345,0.0003890249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003905028,"about_ca_system_score_gemma":0.0003887485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007046,"about_ca_topic_score_gemma":0.0006369426,"domain_scores_codex":[0.999211,0.0002414966,0.00007678067,0.0001144669,0.0002317004,0.0001246052],"domain_scores_gemma":[0.9978535,0.0009847482,0.000585086,0.0001919433,0.0002395685,0.0001451284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001941009,0.00007673872,0.00856857,0.0003618399,0.00004590738,0.0003112483,0.0003030378,0.0003203371,0.9700223,0.007312185,0.0001941844,0.01228947],"study_design_scores_gemma":[0.0001121317,0.003581371,0.3294541,0.0007420423,0.0002997192,0.01034153,0.003066478,0.007777698,0.5507304,0.04558074,0.04821474,0.00009901552],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9806724,0.00649632,0.005367338,0.000603846,0.00002944633,0.00005818076,0.0001642846,0.00006919607,0.006538925],"genre_scores_gemma":[0.9942117,0.001623795,0.003301433,0.0001084193,0.00001968962,0.00003163024,0.0001874713,0.000007456174,0.0005084948],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001534159,"threshold_uncertainty_score":0.005507648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003492787910843084,"score_gpt":0.2320413057376646,"score_spread":0.2285485178268215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}