{"id":"W2156744090","doi":"10.3201/eid2001.130858","title":"Molecular Barriers to Zoonotic Transmission of Prions","year":2013,"lang":"en","type":"article","venue":"Emerging infectious diseases","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Food Inspection Agency","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; University of Edinburgh","keywords":"Chronic wasting disease; Scrapie; Bovine spongiform encephalopathy; Virology; Disease; Prion protein; Pathogenesis; Biology; Gene isoform; Medicine; Immunology; Gene; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004052075,0.0001454151,0.0001333954,0.00008103735,0.0001142138,0.00002378937,0.0001383778,0.00005772836,0.0006136135],"category_scores_gemma":[0.0002184418,0.0001438486,0.0001709544,0.0001557365,0.00003739315,0.000007290654,0.00006808521,0.00004251821,0.00002743904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001217582,"about_ca_system_score_gemma":0.0001057707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007657091,"about_ca_topic_score_gemma":0.000002284865,"domain_scores_codex":[0.9991243,0.00005282274,0.0001912583,0.0002702388,0.0001307282,0.0002306184],"domain_scores_gemma":[0.9990419,0.00000889409,0.00005531621,0.0002858267,0.00009003317,0.0005180723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004480377,0.0001338561,0.03558904,0.0001082435,0.0001306809,0.000004060889,0.00009838361,0.006159106,0.892327,0.0001857748,0.003544664,0.06167438],"study_design_scores_gemma":[0.002919388,0.001735305,0.08132071,0.0004080504,0.0004807171,0.0000228526,0.0005031237,0.001619393,0.7840776,0.003098023,0.1218167,0.001998139],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861284,0.003379879,0.009229432,0.0002527173,0.00009361108,0.0004052171,0.00001824677,0.00004280611,0.0004496974],"genre_scores_gemma":[0.9988205,0.0002184722,0.0002145401,0.0004791087,0.00006020461,0.0001003004,0.00002993464,0.00002581574,0.00005112768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1182721,"threshold_uncertainty_score":0.6718637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003492787910843084,"score_gpt":0.2320413057376646,"score_spread":0.2285485178268215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}