{"id":"W2156786487","doi":"10.1124/mol.110.069054","title":"Differential Signaling of Cysteinyl Leukotrienes and a Novel Cysteinyl Leukotriene Receptor 2 (CysLT2) Agonist, N-Methyl-Leukotriene C4, in Calcium Reporter and β Arrestin Assays","year":2010,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Receptor; Agonist; G protein-coupled receptor; Chemistry; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006345926,0.0004587569,0.0006457099,0.0002430734,0.0001271846,0.00004938258,0.0002853559,0.0005517474,0.0002406623],"category_scores_gemma":[0.0001845631,0.000462292,0.0001529451,0.0002358584,0.0003365952,0.00001718767,0.0003538433,0.0004576097,0.000001804072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002556716,"about_ca_system_score_gemma":0.0001800015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001154914,"about_ca_topic_score_gemma":0.00003810581,"domain_scores_codex":[0.9970747,0.0002071508,0.0008458832,0.0009647334,0.0002798626,0.0006276466],"domain_scores_gemma":[0.9986827,0.00007504784,0.0003922282,0.0003872995,0.0001867318,0.0002760368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003499991,0.0001716944,0.0009218766,0.00008780617,0.0001268311,0.00008543159,0.0001193562,0.0001135401,0.9964523,0.0003250294,0.0001308766,0.001115217],"study_design_scores_gemma":[0.003216513,0.0004857819,0.0002201964,0.00003126938,0.0001110238,0.0001841622,0.00008912259,0.0007554885,0.9903779,0.0001214021,0.003932698,0.0004744642],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9747332,0.0008540199,0.0224422,0.0001613022,0.001070971,0.0005311283,0.00004471426,0.0000254274,0.0001370633],"genre_scores_gemma":[0.9951858,0.0000984852,0.003700209,0.0002386105,0.0003569014,0.00009376933,0.0001144731,0.00007439427,0.0001373528],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02045264,"threshold_uncertainty_score":0.9997829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01024084956514936,"score_gpt":0.2652310063006385,"score_spread":0.2549901567354891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}