{"id":"W2156786487","doi":"10.1124/mol.110.069054","title":"Differential Signaling of Cysteinyl Leukotrienes and a Novel Cysteinyl Leukotriene Receptor 2 (CysLT2) Agonist, N-Methyl-Leukotriene C4, in Calcium Reporter and β Arrestin Assays","year":2010,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Receptor; Agonist; G protein-coupled receptor; Chemistry; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001001499,0.001133279,0.0009880776,0.0008593484,0.0008296026,0.001085988,0.001452121,0.001198506,0.003208697],"category_scores_gemma":[0.0003716959,0.0006142158,0.001006956,0.0008931464,0.000989469,0.0008897374,0.0008346655,0.003394852,0.001014144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00148552,"about_ca_system_score_gemma":0.0008901839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002188336,"about_ca_topic_score_gemma":0.004577057,"domain_scores_codex":[0.9979945,0.0003211792,0.0002180433,0.0004212811,0.0005968462,0.0004480731],"domain_scores_gemma":[0.9993652,0.0001470359,0.000132002,0.0001114943,0.00009286154,0.0001514724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002858567,0.00008443715,0.00004796973,0.00002640423,0.000007231951,0.00002898303,0.00004402575,0.00005328219,0.9987955,0.0003002414,0.00006080261,0.0002651871],"study_design_scores_gemma":[0.00004192514,0.0001302879,0.0004891327,0.000003157493,0.00001184762,0.00004667369,0.00002584882,0.0006285054,0.9977817,0.00004506747,0.0007895462,0.000006234219],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9677824,0.00101708,0.02198922,0.0005594416,0.0002215341,0.0002623186,0.002224688,0.0005380659,0.005405215],"genre_scores_gemma":[0.9398337,0.001880261,0.02513104,0.0002994494,0.00008881767,0.001009417,0.004257526,0.0003212191,0.02717864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003208697,"threshold_uncertainty_score":0.01077831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01024084956514936,"score_gpt":0.2652310063006385,"score_spread":0.2549901567354891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}