{"id":"W2156789260","doi":"10.1093/cvr/cvu218","title":"Nuclear pore rearrangements and nuclear trafficking in cardiomyocytes from rat and human failing hearts","year":2014,"lang":"en","type":"article","venue":"Cardiovascular Research","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"Imperial College London; British Heart Foundation; Wellcome Trust","keywords":"Nuclear transport; Nuclear export signal; Nucleoporin; Nuclear localization sequence; Nuclear pore; Nuclear protein; Importin; Cell nucleus; Cell biology; Muscle hypertrophy; NLS; Cytoplasm; Biology; Internal medicine; Endocrinology; Medicine; Biochemistry; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002006275,0.000166483,0.0001216387,0.0002770133,0.000113702,0.0001142159,0.00009614549,0.0001661316,0.001685601],"category_scores_gemma":[0.0001842741,0.0001130512,0.0001230509,0.0001023033,0.0001894455,0.0001281028,0.0001407418,0.0002290114,0.0003485654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000094688,"about_ca_system_score_gemma":0.00007239456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002201573,"about_ca_topic_score_gemma":0.0002847812,"domain_scores_codex":[0.9999212,0.00001179217,0.000008370823,0.00002351177,0.00002112089,0.00001406914],"domain_scores_gemma":[0.9998964,0.00001960997,0.00003118367,0.00001488906,0.00001232843,0.00002553007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000815491,0.00004916068,0.008841318,0.00007926898,0.0000210211,0.0006907932,0.0001671805,0.00006360663,0.9849148,0.00008964637,0.0001109699,0.00415669],"study_design_scores_gemma":[0.0002419107,0.004327668,0.530752,0.00003462187,0.0001345304,0.01573206,0.0005588892,0.00068596,0.4405903,0.0001655049,0.006750821,0.00002576859],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967603,0.001534269,0.0005480617,0.00003353548,0.00001612223,0.00001505632,0.0002041077,0.00002054049,0.0008679726],"genre_scores_gemma":[0.9968762,0.0007520636,0.0006062303,0.0000356871,0.00001108292,0.00003643343,0.0007325977,0.000009298887,0.0009403467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001685601,"threshold_uncertainty_score":0.005638838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02300501874598295,"score_gpt":0.2791819934644212,"score_spread":0.2561769747184383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}