{"id":"W2156806928","doi":"10.1093/carcin/bgq255","title":"Estrogen receptor α-mediated transcription induces cell cycle-dependent DNA double-strand breaks","year":2010,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale; Alberta Cancer Foundation; University of Calgary","keywords":"RAD51; Biology; Estrogen receptor; Molecular biology; Estrogen; Homologous recombination; Chromatin; Aphidicolin; Chromatin immunoprecipitation; DNA damage; Cancer research; DNA replication; DNA; Cell biology; Promoter; Gene; Gene expression; Biochemistry; Genetics; Cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000159801,0.0002350454,0.0001793557,0.00005734908,0.0001111303,0.00004328515,0.0002536214,0.000331555,0.0001624761],"category_scores_gemma":[0.00000454203,0.0002335208,0.0001608568,0.00009135837,0.00005692838,0.000006037372,0.00003778549,0.0001519819,0.00004099819],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001620934,"about_ca_system_score_gemma":0.0001152966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009442338,"about_ca_topic_score_gemma":0.0001384744,"domain_scores_codex":[0.9987455,0.00003012289,0.0002242314,0.0004640715,0.0001946679,0.0003414215],"domain_scores_gemma":[0.9992053,0.000006570024,0.00007897617,0.0004216086,0.00009883902,0.0001886954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002331953,0.00007637652,0.0004164311,0.0000176587,0.00004915026,0.000002216483,0.00008269733,0.000008683233,0.9951496,0.00009931125,0.00009487974,0.003769849],"study_design_scores_gemma":[0.001665814,0.0001619629,0.0005894094,0.000003656864,0.00005926484,0.000012607,0.00007455107,0.00001013799,0.9712756,0.00003407336,0.0258314,0.0002815023],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962782,0.001028187,0.0003379679,0.0001152824,0.0009739911,0.0002776386,0.00013354,0.00003362466,0.0008215145],"genre_scores_gemma":[0.9977645,0.000384303,0.0002364784,0.0002410032,0.0005077769,0.00006469894,0.0003094762,0.00005457152,0.000437248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02573652,"threshold_uncertainty_score":0.9522702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01122270051264528,"score_gpt":0.2270030543533511,"score_spread":0.2157803538407058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}