{"id":"W2156806928","doi":"10.1093/carcin/bgq255","title":"Estrogen receptor α-mediated transcription induces cell cycle-dependent DNA double-strand breaks","year":2010,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale; Alberta Cancer Foundation; University of Calgary","keywords":"RAD51; Biology; Estrogen receptor; Molecular biology; Estrogen; Homologous recombination; Chromatin; Aphidicolin; Chromatin immunoprecipitation; DNA damage; Cancer research; DNA replication; DNA; Cell biology; Promoter; Gene; Gene expression; Biochemistry; Genetics; Cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001085634,0.0002788257,0.000184681,0.0002240773,0.0001114169,0.0001894277,0.00007523644,0.0001566764,0.002059731],"category_scores_gemma":[0.000126653,0.0001265073,0.0001751099,0.0001336382,0.00014474,0.0000884995,0.0001518641,0.0002068924,0.0005783215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001962234,"about_ca_system_score_gemma":0.0001123957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002975139,"about_ca_topic_score_gemma":0.0005106654,"domain_scores_codex":[0.9999198,0.00001363794,0.000005827272,0.00001910795,0.00002187196,0.00001979606],"domain_scores_gemma":[0.999929,0.00001528138,0.00002033188,0.00001174071,0.00001029835,0.00001339666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001027155,0.00002100781,0.0004375387,0.00005643383,0.000009683063,0.0001083119,0.00001456275,0.00004045861,0.9963954,0.00009115315,0.00007369455,0.00264895],"study_design_scores_gemma":[0.00003143971,0.0008695204,0.01813234,0.00002273608,0.0000267357,0.0008566466,0.00005863543,0.0002548569,0.9652646,0.0001954078,0.01428246,0.000004642035],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9741272,0.01621087,0.003738695,0.000235195,0.0001223819,0.00006715943,0.0006307628,0.0001366824,0.004731064],"genre_scores_gemma":[0.9825993,0.00881312,0.001063672,0.0001050801,0.00003009571,0.00003066578,0.0008112873,0.00001053769,0.006536246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002059731,"threshold_uncertainty_score":0.006890476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01122270051264528,"score_gpt":0.2270030543533511,"score_spread":0.2157803538407058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}