{"id":"W2156850997","doi":"10.1053/j.gastro.2010.08.051","title":"Induction Pegylated Interferon Alfa-2a and High Dose Ribavirin Do Not Increase SVR in Heavy Patients With HCV Genotype 1 and High Viral Loads","year":2010,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Vertex Pharmaceuticals; Gilead Sciences; Roche; GlaxoSmithKline; Genentech; Amylin Pharmaceuticals; Pfizer; Bristol-Myers Squibb; Valeant Pharmaceuticals International; Abbott Laboratories","keywords":"Ribavirin; Medicine; Gastroenterology; Internal medicine; Pegylated interferon; Viral load; Hepatitis C virus; Odds ratio; Peginterferon alfa-2a; Confidence interval; Randomized controlled trial; Hepatology; Hepatitis C; Virology; Virus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006134138,0.0002257069,0.0009304282,0.0001559757,0.0002313926,0.0003355911,0.0002532633,0.0004901425,0.00386949],"category_scores_gemma":[0.002511024,0.0001705237,0.0006059798,0.0001907542,0.0002807356,0.0005632205,0.0003107245,0.0008864711,0.0004111986],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002473519,"about_ca_system_score_gemma":0.0004142024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004751155,"about_ca_topic_score_gemma":0.0009968627,"domain_scores_codex":[0.9997211,0.0001373568,0.00001681901,0.00002283288,0.00003678455,0.000065015],"domain_scores_gemma":[0.997951,0.0009357681,0.0002643027,0.0001406849,0.00003038526,0.0006779321],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3071629,0.006352041,0.3093311,0.0003792776,0.001047682,0.0009272742,0.0002575991,0.0015045,0.01993427,0.0006028729,0.005221469,0.347279],"study_design_scores_gemma":[0.01397014,0.0261748,0.9504296,0.00006482477,0.0005205036,0.001111083,0.0001982235,0.001983402,0.001759896,0.0008819049,0.002876403,0.00002935584],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961988,0.0008660445,0.00009330366,0.0005091878,0.00006496585,0.00001903828,0.00008450355,0.00003436679,0.002129794],"genre_scores_gemma":[0.9989043,0.0001991896,0.0001656408,0.0002490849,0.00006386222,0.000007615371,0.0001100527,0.000005382179,0.0002948024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00386949,"threshold_uncertainty_score":0.01294476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00893106351081927,"score_gpt":0.2500856713823911,"score_spread":0.2411546078715718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}