{"id":"W2156850997","doi":"10.1053/j.gastro.2010.08.051","title":"Induction Pegylated Interferon Alfa-2a and High Dose Ribavirin Do Not Increase SVR in Heavy Patients With HCV Genotype 1 and High Viral Loads","year":2010,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Vertex Pharmaceuticals; Gilead Sciences; Roche; GlaxoSmithKline; Genentech; Amylin Pharmaceuticals; Pfizer; Bristol-Myers Squibb; Valeant Pharmaceuticals International; Abbott Laboratories","keywords":"Ribavirin; Medicine; Gastroenterology; Internal medicine; Pegylated interferon; Viral load; Hepatitis C virus; Odds ratio; Peginterferon alfa-2a; Confidence interval; Randomized controlled trial; Hepatology; Hepatitis C; Virology; Virus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002704202,0.0002389486,0.0004280447,0.0003642466,0.00006061575,0.00003188675,0.000100045,0.0002181818,0.0001844017],"category_scores_gemma":[0.0001140058,0.0002012207,0.00002197033,0.0001258773,0.0003632654,0.0001746119,0.0001938112,0.0009120549,0.00002469012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008131282,"about_ca_system_score_gemma":0.00004508827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003155738,"about_ca_topic_score_gemma":0.004201479,"domain_scores_codex":[0.9980965,0.0002073754,0.0003415562,0.0005123771,0.0002671086,0.0005751044],"domain_scores_gemma":[0.9991078,0.00003509604,0.00008661412,0.0003321941,0.0001353147,0.0003029598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01295972,0.0003155111,0.9620653,0.00003887503,0.00005157629,0.00009349037,0.0001747131,0.000001283813,0.008733612,0.0000269591,0.0001180082,0.01542093],"study_design_scores_gemma":[0.009088445,0.00599303,0.9836294,0.00004392323,0.00003728974,0.00006667801,0.00001427999,0.00009618158,0.0005205917,0.00004062887,0.0003690251,0.0001004933],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997905,0.00001526148,0.0000334841,0.001140917,0.000220707,0.0005549488,0.00004718445,0.00003717888,0.00004531176],"genre_scores_gemma":[0.9984772,0.00003846227,0.000533453,0.0005693627,0.0001060553,0.0000404382,0.0001554058,0.00003738943,0.00004220835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02156411,"threshold_uncertainty_score":0.8205544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00893106351081927,"score_gpt":0.2500856713823911,"score_spread":0.2411546078715718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}