{"id":"W2156861039","doi":"10.1021/ac5044187","title":"Emulsion PCR Significantly Improves Nonequilibrium Capillary Electrophoresis of Equilibrium Mixtures-Based Aptamer Selection: Allowing for Efficient and Rapid Selection of Aptamer to Unmodified ABH2 Protein","year":2014,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Aptamer; Systematic evolution of ligands by exponential enrichment; Chemistry; Capillary electrophoresis; DNA; Chromatography; Computational biology; Molecular biology; RNA; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008171487,0.0008324371,0.0004165024,0.0003586807,0.0001326795,0.000633323,0.0004754127,0.0005498498,0.0009037253],"category_scores_gemma":[0.001221237,0.0002814471,0.0002696236,0.000205502,0.0004112896,0.0004744968,0.0005701654,0.000848478,0.0004753357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002576608,"about_ca_system_score_gemma":0.0002810115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000461232,"about_ca_topic_score_gemma":0.0006597693,"domain_scores_codex":[0.9991986,0.0001275043,0.00006036633,0.0002289798,0.0002993663,0.00008523749],"domain_scores_gemma":[0.9995013,0.0002255581,0.00008569773,0.00003908023,0.0001105959,0.00003780258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002226123,0.00002847996,0.00009636225,0.00003569959,0.000004708858,0.00006435512,0.00002396076,0.0001983964,0.9948393,0.0001383589,0.00004704969,0.004501073],"study_design_scores_gemma":[0.000003197547,0.00005087582,0.0002203818,0.000002174266,0.000007641785,0.0001317157,0.000003197205,0.002169568,0.9964026,0.00003335124,0.0009697824,0.000005501006],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6247814,0.004763636,0.3634824,0.0004277249,0.0001428244,0.0002800527,0.0002277809,0.001776791,0.004117238],"genre_scores_gemma":[0.8262569,0.002265858,0.1650988,0.000274303,0.00003667604,0.0001264732,0.0004438142,0.0002776715,0.005219492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009037253,"threshold_uncertainty_score":0.004321575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00732082235245856,"score_gpt":0.2489102901341355,"score_spread":0.2415894677816769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}