{"id":"W2156861039","doi":"10.1021/ac5044187","title":"Emulsion PCR Significantly Improves Nonequilibrium Capillary Electrophoresis of Equilibrium Mixtures-Based Aptamer Selection: Allowing for Efficient and Rapid Selection of Aptamer to Unmodified ABH2 Protein","year":2014,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Aptamer; Systematic evolution of ligands by exponential enrichment; Chemistry; Capillary electrophoresis; DNA; Chromatography; Computational biology; Molecular biology; RNA; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002831286,0.0002678205,0.0004240392,0.00007721777,0.00006175616,0.00001784009,0.0001415124,0.0002863726,0.00000494667],"category_scores_gemma":[0.0003394751,0.0002408635,0.0002475785,0.0003230898,0.0001652001,0.000004641765,0.00006400091,0.0001260715,2.548092e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002890743,"about_ca_system_score_gemma":0.00006719901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001845805,"about_ca_topic_score_gemma":0.000002522173,"domain_scores_codex":[0.9982926,0.00005165129,0.0004592255,0.0006126181,0.0002320605,0.0003518326],"domain_scores_gemma":[0.9989705,0.00005094455,0.0001947366,0.0002952556,0.0003376821,0.0001508466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005865151,0.0001240602,0.00008900595,0.0002085702,0.0001090876,2.821978e-7,0.000005187809,0.0002350194,0.9972996,0.00000810658,0.0002078016,0.001126822],"study_design_scores_gemma":[0.0004280057,0.0007250955,0.00009997259,0.00005189783,0.0001459505,0.000003703005,0.00001360256,0.03606494,0.9615836,0.00002036667,0.000591895,0.0002709299],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981133,0.0001047964,0.01805537,0.0001603566,0.00001316386,0.0003416815,0.00001410999,0.00003401841,0.0001434526],"genre_scores_gemma":[0.9926025,0.00001090042,0.006792452,0.00008255068,0.0001578476,0.00002872163,0.00007418295,0.00003282075,0.0002180562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03582992,"threshold_uncertainty_score":0.9822128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00732082235245856,"score_gpt":0.2489102901341355,"score_spread":0.2415894677816769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}