{"id":"W2156876193","doi":"10.1093/emboj/21.3.314","title":"A ‘three‐pronged’ binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome","year":2002,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":86,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Western University; University of Toronto","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Biology; SH2 domain; Phosphorylation; Binding domain; Plasma protein binding; Binding site; Mutant; Cell biology; Gene; Computational biology; Genetics; Biochemistry; Proto-oncogene tyrosine-protein kinase Src","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003428985,0.0006199559,0.00052131,0.0002251105,0.0006498292,0.000791401,0.001276088,0.001929885,0.003799647],"category_scores_gemma":[0.0003668516,0.0003817251,0.0005905218,0.0001563317,0.0008729692,0.001062525,0.0007725739,0.001750938,0.001415931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000529122,"about_ca_system_score_gemma":0.0002918493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005326018,"about_ca_topic_score_gemma":0.0004539298,"domain_scores_codex":[0.9997604,0.0000323456,0.00001973077,0.00006036929,0.00005853458,0.0000685963],"domain_scores_gemma":[0.9997389,0.00005481011,0.00005417671,0.00004655335,0.00002912795,0.00007649831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004914016,0.0001016784,0.001733076,0.0001378981,0.00003459802,0.004946731,0.0001433255,0.001859682,0.9707143,0.009815582,0.001371982,0.008649666],"study_design_scores_gemma":[0.0002629481,0.0004843085,0.01123703,0.00002831915,0.0000719887,0.01667677,0.0002234033,0.03283715,0.9148303,0.009213395,0.01399796,0.0001363722],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9619637,0.0009593429,0.03168117,0.0009881502,0.0002769708,0.00003456324,0.0001859359,0.0005214881,0.003388591],"genre_scores_gemma":[0.9922447,0.0001320486,0.005421781,0.0003432483,0.00003272742,0.00001727576,0.0001325705,0.00002822249,0.001647509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003799647,"threshold_uncertainty_score":0.01271111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02016817694238143,"score_gpt":0.2316193358556283,"score_spread":0.2114511589132469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}