{"id":"W2156876193","doi":"10.1093/emboj/21.3.314","title":"A ‘three‐pronged’ binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome","year":2002,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":86,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Western University; University of Toronto","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Biology; SH2 domain; Phosphorylation; Binding domain; Plasma protein binding; Binding site; Mutant; Cell biology; Gene; Computational biology; Genetics; Biochemistry; Proto-oncogene tyrosine-protein kinase Src","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006130535,0.0001555969,0.0001595771,0.00005830505,0.001921735,0.0001107792,0.0003589026,0.00008130782,0.001599463],"category_scores_gemma":[0.0001654928,0.00006993164,0.0001204764,0.0001065579,0.0001072909,0.0001364064,0.00007437202,0.000656792,0.0003262088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005631229,"about_ca_system_score_gemma":0.0000100643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002104858,"about_ca_topic_score_gemma":0.00004051124,"domain_scores_codex":[0.9990439,0.0001529386,0.000261221,0.0001539918,0.00005739698,0.0003305166],"domain_scores_gemma":[0.9989778,0.000483635,0.0001629645,0.0002690025,0.00008268563,0.00002385343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002004034,0.0001202035,0.0003023066,0.00004491343,0.002449962,0.00003784794,0.01820511,0.0001750383,0.4926835,0.0375334,0.3362259,0.1102179],"study_design_scores_gemma":[0.005338612,0.002169433,0.006582983,0.0002567341,0.0006045268,0.05120923,0.0119881,0.002054676,0.03591525,0.02344869,0.8595031,0.0009286581],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9488478,0.004020366,0.008195661,0.03003942,0.007838293,0.0006245078,0.000008372896,0.00003523974,0.0003903067],"genre_scores_gemma":[0.9900722,0.000370578,0.0001419543,0.001547597,0.0002088782,0.00003595818,0.00000268628,0.00002011,0.00760005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5232772,"threshold_uncertainty_score":0.9993776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02016817694238143,"score_gpt":0.2316193358556283,"score_spread":0.2114511589132469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}