{"id":"W2156891220","doi":"10.1128/aac.01442-07","title":"Clinical Outcomes, Safety, and Pharmacokinetics of OPT-80 in a Phase 2 Trial with Patients with<i>Clostridium difficile</i>Infection","year":2008,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; University of Calgary","funders":"Viropharma; GlaxoSmithKline; Pfizer","keywords":"Dose; Clostridium difficile; Diarrhea; Medicine; Gastroenterology; Pharmacokinetics; Internal medicine; Clinical trial; Feces; Randomized controlled trial; Surgery; Antibiotics; Microbiology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001637164,0.0008915904,0.001749798,0.0002769671,0.0003147643,0.0008603927,0.0005094983,0.001108753,0.001458629],"category_scores_gemma":[0.001473624,0.0004003416,0.0007234032,0.0002904072,0.000839268,0.0006819064,0.0002536626,0.001913069,0.0004063983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005108195,"about_ca_system_score_gemma":0.000867154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000404821,"about_ca_topic_score_gemma":0.0007231023,"domain_scores_codex":[0.9994405,0.0003424005,0.00002675984,0.00005740518,0.00004014275,0.00009271864],"domain_scores_gemma":[0.9992515,0.0001809117,0.00018551,0.00005219488,0.00005364627,0.0002762636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8106915,0.03831026,0.006598173,0.0006150426,0.0006422774,0.0002862855,0.0003167285,0.003379219,0.03233565,0.0002905593,0.002719711,0.1038145],"study_design_scores_gemma":[0.4795261,0.5040904,0.009473335,0.00003895308,0.0002741733,0.0002627835,0.00005455581,0.001691816,0.002863672,0.0001872442,0.001497368,0.00003959685],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959993,0.001424889,0.0002930628,0.0002248403,0.00004630461,0.0006762625,0.0002264231,0.00003669776,0.001072295],"genre_scores_gemma":[0.9941263,0.001123472,0.000872459,0.0006141686,0.0001144517,0.001646476,0.000576407,0.00001693377,0.0009092609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001749798,"threshold_uncertainty_score":0.00865823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02788111864419147,"score_gpt":0.3334120469538082,"score_spread":0.3055309283096168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}