{"id":"W2156891220","doi":"10.1128/aac.01442-07","title":"Clinical Outcomes, Safety, and Pharmacokinetics of OPT-80 in a Phase 2 Trial with Patients with<i>Clostridium difficile</i>Infection","year":2008,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; University of Calgary","funders":"Viropharma; GlaxoSmithKline; Pfizer","keywords":"Dose; Clostridium difficile; Diarrhea; Medicine; Gastroenterology; Pharmacokinetics; Internal medicine; Clinical trial; Feces; Randomized controlled trial; Surgery; Antibiotics; Microbiology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001829275,0.0002953782,0.0007684235,0.0001686805,0.0001034727,0.00001770888,0.00007077584,0.0001479017,0.0001054619],"category_scores_gemma":[0.00002538127,0.0002082124,0.0001039274,0.0003081186,0.0003785985,0.00007121647,0.00004703694,0.0003428051,0.000001915857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004371162,"about_ca_system_score_gemma":0.0001297107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001864508,"about_ca_topic_score_gemma":0.00002286465,"domain_scores_codex":[0.9980957,0.00006197632,0.000659248,0.0004569699,0.0003667836,0.0003593456],"domain_scores_gemma":[0.9991415,0.00008005254,0.0001852906,0.0002375201,0.0001557048,0.0001999075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1028325,0.006404767,0.8742126,0.0001152538,0.0002897331,0.00007712514,0.0001910983,0.00000344589,0.002099852,0.000004114806,0.001977852,0.01179166],"study_design_scores_gemma":[0.3411518,0.007372501,0.6173346,0.0001758846,0.0001641939,0.00007254721,0.00001647917,0.00008422157,0.02063914,0.000001005246,0.01260528,0.0003823759],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972644,0.00002545378,0.00002996437,0.001119062,0.00009539228,0.001225462,0.00005927225,0.00002317619,0.0001578342],"genre_scores_gemma":[0.9929547,0.00548724,0.000181078,0.0009336242,0.0001242991,0.000008284777,0.00007749171,0.00004499573,0.0001882538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.256878,"threshold_uncertainty_score":0.8490654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02788111864419147,"score_gpt":0.3334120469538082,"score_spread":0.3055309283096168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}