{"id":"W2156954189","doi":"10.1152/ajpheart.01097.2006","title":"Nitric oxide attenuates endothelin-1-induced activation of ERK1/2, PKB, and Pyk2 in vascular smooth muscle cells by a cGMP-dependent pathway","year":2007,"lang":"en","type":"article","venue":"American Journal of Physiology-Heart and Circulatory Physiology","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research; Heart And Stroke Foundation Of Quebec","keywords":"Nitric oxide; Sodium nitroprusside; Vascular smooth muscle; Soluble guanylyl cyclase; Endothelin 1; Signal transduction; Snap; Phosphorylation; Chemistry; Endocrinology; Internal medicine; cGMP-dependent protein kinase; Protein kinase B; Endothelin receptor; Protein kinase A; Cell biology; Biology; Biochemistry; Receptor; Medicine; Cyclic gmp; Smooth muscle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007862413,0.0002779398,0.001130436,0.0004087964,0.00005845177,0.000004756208,0.0001124626,0.0001570955,0.00001923535],"category_scores_gemma":[0.00009879197,0.0002307979,0.0001974398,0.0003451543,0.0004386967,0.0001225136,0.0000503203,0.0005256157,0.000004617017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006481205,"about_ca_system_score_gemma":0.0001210418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002078615,"about_ca_topic_score_gemma":0.000003101187,"domain_scores_codex":[0.9979193,0.0002760667,0.0007202128,0.0004003081,0.0002335435,0.0004505848],"domain_scores_gemma":[0.9981958,0.0005157443,0.0006115178,0.0002886496,0.000165623,0.0002226093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004123423,0.0003002604,0.002918217,0.00008759375,0.0001398568,0.000003637178,0.0002320727,0.00002088429,0.9903682,0.00001251219,0.00003358249,0.005470805],"study_design_scores_gemma":[0.002231198,0.001101612,0.7287812,0.00009134612,0.00008292048,0.00003634644,0.0006110906,0.00004076412,0.2662631,0.0003264135,0.0002514492,0.0001824846],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986865,0.0008617614,0.00001746139,0.00007177611,0.00008998218,0.0002333034,0.000007248299,0.00001330597,0.00001869772],"genre_scores_gemma":[0.9985189,0.0003418126,0.0002141853,0.000701772,0.0001722923,0.000004844529,0.000006079856,0.00003342087,0.000006715599],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.725863,"threshold_uncertainty_score":0.9411666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009319003371693585,"score_gpt":0.2387660932033053,"score_spread":0.2294470898316117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}